Thrombogenicity assessment of Pipeline Flex, Pipeline Shield, and FRED flow diverters in an in vitro human blood physiological flow loop model

Journal of Biomedical Materials Research. Part a
Gaurav GirdharMichael F Wolf

Abstract

Endovascular treatment of intracranial aneurysms with endoluminal flow diverters (single or multiple) has proven to be clinically safe and effective, but is associated with a risk of thromboembolic complications. Recently, a novel biomimetic surface modification with covalently bound phosphorylcholine (Shield Technology™) has shown to reduce the material thrombogenicity of the Pipeline flow diverter. Thrombogenicity of Pipeline Flex, Pipeline Shield, and Flow Redirection Endoluminal Device (FRED) in the presence of human blood under physiological flow conditions-in addition to relative increase in thrombogenicity with multiple devices-remains unknown and was investigated here. Thrombin generation (mean ± SD; μg/mL; thrombin-antithrombin complex or TAT) was measured as FRED (30.3 ± 2.9), Pipeline (13.9 ± 4.4), Pipeline Shield (0.4 ± 0.3), and negative control (no device; 0.1 ± 0.0). Platelet activation (mean ± SD; IU/μL; beta-thromboglobulin or βTG) was measured as FRED (148 ± 45), Pipeline (92.8 ± 41), Pipeline Shield (16.2 ± 3.5), and negative control (2.70 ± 0.16). FRED was significantly more thrombogenic than Pipeline and Pipeline Shield (p < 0.05) for TAT. Additionally, Pipeline Shield had significantly lower TAT and βTG th...Continue Reading

References

Oct 25, 2002·Journal of Vascular and Interventional Radiology : JVIR·Gunnar TepeStephan H Duda
Jun 28, 2005·Journal of Thrombosis and Haemostasis : JTH·K Brummel-ZiedinsK G Mann
Sep 4, 2008·Thrombosis and Haemostasis·Jolanta M Siller-MatulaBernd Jilma
Dec 15, 2010·AJNR. American Journal of Neuroradiology·P K NelsonD Fiorella
May 24, 2011·Journal of Materials Science. Materials in Medicine·Stefan SinnHans P Wendel
Feb 19, 2014·Neurological Research·Scott L ZuckermanJ Mocco
Jun 27, 2014·Stroke Research and Treatment·Yazan J AlderaziChirag D Gandhi
Nov 22, 2014·Journal of Neurointerventional Surgery·Robert M StarkeRaymond D Turner
May 16, 2015·Journal of Thrombosis and Thrombolysis·Gaurav GirdharWayne L Chandler
Sep 30, 2016·Journal of Neurointerventional Surgery·Albert Ho Yuen ChiuAndrew Cheung
Nov 2, 2016·Journal of Neurointerventional Surgery·Matthew W HagenMonica T Hinds
Jan 1, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Akiko SekiyaEriko Morishita
Jun 9, 2017·Journal of Neurointerventional Surgery·Yoshikazu MatsudaDemetrius K Lopes
Jul 10, 2017·Journal of Neurointerventional Surgery·Miklos MarosfoiAjit S Puri

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Citations

Mar 7, 2019·The Neuroradiology Journal·Christopher R PasarikovskiVictor Xd Yang
Jul 31, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Takashi FujiiHajime Arai
Sep 16, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael F WolfCarrie A Strief
Mar 11, 2020·Der Radiologe·Ruben Mühl-Benninghaus
Jun 4, 2020·Journal of Neurointerventional Surgery·Robert M StarkeGaurav Girdhar
Sep 27, 2020·Journal of Neurointerventional Surgery·Sudeepta DandapatSantiago Ortega-Gutierrez
Jan 30, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Derek C SamplesRamesh Grandhi
Jul 9, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Pervinder BhogalHans Henkes
Sep 14, 2021·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Cemal A GündoğmuşFeyyaz Baltacıoğlu

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Methods Mentioned

BETA
ELISA
scanning electron microscopy

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