PMID: 5902237Jan 29, 1966

Thrombohemorrhagic response to noradrenaline following heterologous blood transfusion: a preliminary report

Canadian Medical Association Journal
H SelyeB Tuchweber


Normal rats are extremely tolerant to heterologous blood transfusion; however, after subcutaneous injection of noradrenaline, they lose this tolerance and respond with severe thrombohemorrhagic reactions both at the site of injection and in internal organs, particularly the kidney.In histological structure, the topical and general manifestations of this thrombohemorrhagic response are virtually identical with those of the local and general Sanarelli-Shwartzman phenomenon, respectively.Among the blood specimens tested, those of the dog, cat, rabbit, guinea pig, chicken and man were most effective in inducing this type of noradrenaline hypersensitivity. The blood of the duck and hamster as well as homologous rat blood proved to be virtually or completely inefficacious.The possible theoretical and clinical implications of a noradrenaline test for potential blood-borne thrombohemorrhagic factors are briefly discussed.

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