PMID: 2123901Dec 1, 1990Paper

Thrombolysis in Myocardial Infarction (TIMI) phase II trial: outcome comparison of a "conservative strategy" in community versus tertiary hospitals. The TIMI Research Group

Journal of the American College of Cardiology
F FeitG L Knatterud

Abstract

In the conservative strategy arm of phase II of the Thrombolysis in Myocardial Infarction (TIMI) trial, 1,461 patients were treated with intravenous recombinant tissue-type plasminogen activator (rt-PA). Coronary angiography, with angioplasty if feasible, was to be performed only for recurrent spontaneous or exercise-induced ischemia. In this study results in patients treated by this strategy in community and tertiary hospitals are compared. Despite similar baseline findings in the two groups, coronary angiography was performed within 42 days in more patients (542 [48%] of 1,155) initially admitted to a tertiary hospital (on-site coronary angiography/angioplasty available) than in those (94 [32%] of 306) admitted to a community hospital (transfer to tertiary hospital for coronary angiography/angioplasty) (p less than 0.001). This different approach resulted in a greater use of coronary angioplasty (203 [18%] of 1,155 versus 32 [11%] of 306, p less than 0.01), coronary artery bypass surgery (133 [12%] of 1,155 versus 23 [8%] of 306, p less than 0.05) and blood transfusions (139 [12%] of 1,155 versus 17 [5.5%] of 306, p less than 0.001) in patients admitted to a tertiary than to a community hospital. However, there were no signif...Continue Reading

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References

Oct 1, 1987·Journal of the American College of Cardiology·E BraunwaldR Solomon
Apr 1, 1986·Journal of the American College of Cardiology·P W SerruysW J Remme

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Citations

Feb 1, 1993·The Journal of the Association of Physicians of India·S Sharma, H S Wasir
Mar 11, 1993·The New England Journal of Medicine·R A Lange, L D Hillis
Jan 3, 1992·The American Journal of Cardiology·A J Tiefenbrunn
Dec 1, 1993·Journal of the American College of Cardiology·M L TerrinE Braunwald
Dec 1, 1990·Journal of the American College of Cardiology·E M Geltman
Mar 9, 1995·Journal of Interventional Cardiology·C P CannonE M Antman

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