PMID: 2108856Apr 1, 1990Paper

Thrombolysis in venous thromboembolism. An international perspective

Chest
S Z Goldhaber

Abstract

Two promising novel recombinant tissue-type plasminogen activator (rt-PA) regimens for pulmonary embolism (PE) are being actively investigated: 100 mg/2 h as a continuous peripheral intravenous infusion, and bolus rt-PA, adjusted to weight, as a 2-min infusion. For deep venous thrombosis (DVT), less progress has been made in finding an optimal dosing regimen of rt-PA. Our mandate for the 1990s is to use the best possible thrombolytic dosing regimens in large clinical trials of PE and DVT. The primary objective of these planned clinical studies is to determine which patients with PE and DVT will benefit the most from thrombolysis followed by anticoagulation rather than anticoagulation alone.

Citations

Oct 12, 2000·Journal of the American College of Cardiology·J SchweizerA Graf
Apr 1, 1996·European Journal of Oral Sciences·J M NautaA Vermey
Jun 1, 1993·Photochemistry and Photobiology·S Andersson-EngelsS Svanberg
Mar 29, 2000·Journal of Vascular and Interventional Radiology : JVIR·C P SembaD L Warner
Sep 1, 1991·Progress in Cardiovascular Diseases·S Sherry, V J Marder
Sep 21, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M GrünewaldH Osterhues

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