Thrombolysis outcomes among obese and overweight stroke patients: an age- and National Institutes of Health Stroke Scale-matched comparison

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Raymond C S SeetAlejandro A Rabinstein

Abstract

Whether obese and overweight stroke patients respond differently to intravenous thrombolysis is unclear. The purpose of this study is to determine the influence of obesity and risk components of metabolic syndrome to stroke recovery in patients undergoing intravenous thrombolysis. Outcomes after recombinant tissue plasminogen activator treatment were compared between obese (body mass index [BMI] >30 kg/m(2)), overweight (BMI 25-30 kg/m(2)), and normal weight (BMI <25 kg/m(2)) patients. The association between BMI, risk components of the metabolic syndrome, and dose of recombinant tissue plasminogen activator per kilogram of body weight to stroke outcomes were assessed in a multivariable model. A total of 169 patients (mean age 75 years; baseline National Institutes of Health Stroke Scale score 11) were included. No differences in the frequency of symptomatic intracranial hemorrhage and poor functional recovery were observed among obese, overweight, and normal weight patients. A linear trend toward worse stroke recovery was observed in patients with a greater number of metabolic risk components (P for trend .043). By contrast, there were no significant associations between the number of risk components of metabolic syndrome with...Continue Reading

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Citations

Aug 2, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H GensickeUNKNOWN Thrombolysis in Stroke Patients (TriSP) collaborators
Sep 23, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael J Haley, Catherine B Lawrence
Mar 4, 2020·Eating and Weight Disorders : EWD·Stefano ForlivesiBruno Bonetti
Mar 16, 2017·PloS One·Lisa OeschHakan Sarikaya
May 8, 2020·Lipids in Health and Disease·Nicolas PouporeThomas I Nathaniel
Dec 23, 2019·Translational Stroke Research·Michael J HaleyCatherine B Lawrence
Mar 9, 2021·ERJ Open Research·Chinthaka B SamaranayakeJohn W Upham
Apr 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peng ZhangYi Yang
Jun 29, 2021·Frontiers in Neuroscience·Jennifer A LiuRandy J Nelson

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