Thrombolytic therapy does not change the release ratios of enzymatic and non-enzymatic myocardial marker proteins

Clinica Chimica Acta; International Journal of Clinical Chemistry
K W WodzigW T Hermens


Measurements of cardiac marker proteins in plasma from patients with acute myocardial infarction (AMI) have become important in the evaluation of recanalization therapy. The validity of this approach has however been questioned, because it was claimed that coronary reperfusion may increase the recovery in plasma of cardiac enzymes, such as creatine kinase (CK). In the present study, possible effects of thrombolytic therapy on the release of enzymatic and nonenzymatic marker proteins were investigated. Activities of CK and lactate dehydrogenase (LDH), and concentrations of myoglobin (Mb) and fatty acid-binding protein (FABP) were determined in serial plasma samples obtained from 50 patients with confirmed AMI, of whom 36 received thrombolytic therapy, and 14 did not. Treatment delay was 2.8+/-1.6 (mean+/-SD) h, and hospital delay in untreated patients was 2.7+/-1.8 h. Average infarct size, expressed in gram-equivalents of heart muscle per litre of plasma (g-eq/l), varied between 5.5 and 7.2 g-eq/l for the four marker proteins in patients treated with thrombolytic therapy, and between 4.6 and 6.4 g-eq/l in untreated patients, with a tendency to larger infarct sizes for Mb and FABP than for CK and LDH. Thrombolytic therapy, althou...Continue Reading


Apr 1, 1978·The Journal of Clinical Investigation·S F VatnerP R Maroko
Sep 1, 1975·Archives of Biochemistry and Biophysics·J F Dice, A L Goldberg
Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Sep 30, 1970·Biochemical and Biophysical Research Communications·P J Dehlinger, R T Schimke
Feb 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·T Groth, C Sylvén
Mar 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K W WodzigM P van Dieijen-Visser

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