Thrombolytic therapy for acute stroke in Austria: data from the Safe Implementation of Thrombolysis in Stroke (SITS) register.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
R TopakianSITS-Austria group

Abstract

We aimed at determining the safety and efficacy of IV alteplase in Austrian versus non-Austrian centres as documented in the Internet-based registers Safe Implementation of Thrombolysis for Stroke - MOnitoring STudy (SITS-MOST) and - International Stroke Thrombolysis Register (SITS-ISTR). We analysed patient data entered in the registers SITS-MOST and SITS-ISTR in the period December 2002 to 15 November 2007. Compared to the non-Austrian cohort (n=15153), the Austrian cohort (n=896) was slightly older [median, interquartile range (IQR): 70, 60-77 years vs. 69, 60-76 years, P=0.05] and included more women (44.6% vs. 41.0%, P=0.03). Austrian patients had a significantly shorter stroke onset-to-treatment time (OTT; median, IQR: 135, 105-160 min vs. 145, 115-170 min, P<0.0005). Symptomatic intracerebral haemorrhages were observed in 1.6% of Austrian and 1.7% of non-Austrian patients (P=0.82). At 3 months, 50.8% of Austrian and 53.0% of non-Austrian patients were independent (P=0.23), but death was less frequent in Austrian patients (12.1% vs. 14.9%, P=0.03). Multivariate analyses adjusted for demographic and baseline characteristics confirmed lower mortality at 3 months in the Austrian cohort (odds ratio 0.81, 95% confidence interv...Continue Reading

References

Nov 1, 1988·Stroke; a Journal of Cerebral Circulation·R F Bloch
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Mar 22, 2003·Cerebrovascular Diseases·Michael BraininUNKNOWN Austrian Stroke Registry for Acute Stroke Units
Jun 26, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M M SteinerUNKNOWN Austrian Stroke Registry for Acute Stroke Units
Mar 16, 2004·Lancet·Werner HackeUNKNOWN NINDS rt-PA Study Group Investigators
Feb 3, 2007·Cerebrovascular Diseases·Didier LeysUNKNOWN European Stroke Initiative Executive Committee
Jun 22, 2007·Lancet Neurology
Sep 29, 2007·Stroke; a Journal of Cerebral Circulation·Didier LeysUNKNOWN Executive Committee of the European Stroke Initiative
Oct 19, 2007·The Cochrane Database of Systematic Reviews·UNKNOWN Stroke Unit Trialists' Collaboration
May 15, 2008·Cerebrovascular Diseases·UNKNOWN European Stroke Organisation (ESO) Executive Committee, UNKNOWN ESO Writing Committee
Sep 4, 2008·Wiener medizinische Wochenschrift·Michael Brainin, Wilfried Lang
Sep 4, 2008·Wiener medizinische Wochenschrift·Christine HoferWilfried Lang
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Nils WahlgrenUNKNOWN Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators
Nov 29, 2008·Cerebrovascular Diseases·E Bernd RingelsteinUNKNOWN European Stroke Initiative executive committe

❮ Previous
Next ❯

Citations

Sep 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H Schapira, M Hillbom
Sep 27, 2013·PloS One·Julia FerrariUNKNOWN Austrian Stroke Unit Registry Collaborators
Apr 20, 2013·AJNR. American Journal of Neuroradiology·P C SanelliD K Hallam
Aug 24, 2013·Expert Review of Neurotherapeutics·Vijay K SharmaNabin Sarkar
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Jul 24, 2018·Therapeutic Advances in Neurological Disorders·Georgios TsivgoulisGeorgios Hadjigeorgiou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.