Thrombolytic therapy for pulmonary embolism

The Cochrane Database of Systematic Reviews
B DongT Wu

Abstract

Thrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clot more rapidly than heparin and might reduce the death rate associated with PE. However, there are still concerns about the possible risk of adverse effects of thrombolytic therapy, such as major or minor haemorrhages. To assess the effectiveness and safety of thrombolytic therapy in patients with acute PE. We sought trials through the Cochrane Peripheral Vascular Diseases Group's Specialised Register (January 18, 2006), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 1, 2006), MEDLINE (January 1966 to December 2004), EMBASE, CINAHL, LILACS and SCISEARCH (all November 2004). We also searched individual trial collections and private databases, along with bibliographies of relevant articles. Relevant medical journals were handsearched. The most recent search was on February 6, 2006. Randomised controlled trials that compared thrombolytic therapy with placebo or heparin or surgical intervention in patients with acute PE. We did not include trials comparing two different thrombolytic agents or different doses of the...Continue Reading

Citations

Mar 2, 2013·Seminars in Interventional Radiology·Nael Saad
Jun 10, 2009·Internal and Emergency Medicine·Alessandro SquizzatoAndrea A Conti
Dec 19, 2018·The Cochrane Database of Systematic Reviews·Qiukui HaoGuan J Liu
Oct 1, 2015·The Cochrane Database of Systematic Reviews·Qiukui HaoGuan J Liu
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Zhiliang ZuoQiukui Hao

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