Thrombolytic therapy in acute ischaemic stroke

Cerebrovascular Diseases
L ThomassenDavid Russell

Abstract

The aim of this study was to assess the feasibility, clinical effect and safety of intravenous thrombolysis with tissue plasminogen activator in patients with acute ischaemic stroke treated in an acute stroke unit. All patients admitted within 3 h after an acute ischaemic stroke were considered for thrombolysis. Twenty-four patients were treated. Ten patients demonstrated early clinical improvement compatible with a positive effect of thrombolysis. Five patients demonstrated a substantial but slow clinical improvement with an uncertain relationship to thrombolysis. Nine patients did not improve. One patient developed an intracerebral haematoma and 2 developed a haemorrhagic infarction without clinical deterioration. Five patients (21%) died within the first 3 months. At follow-up after 6 months, 10 patients (42%) had achieved independence [modified Rankin Scale (mRS) 0-2], 9 (33%) had an unfavourable outcome (mRS 3-5) and 5 patients (21%) had died. None of these 5 patients died due to a treatment complication. This study in a small patient population suggests that thrombolysis may be administered relatively safely in an acute stroke unit without intensive care facilities. The clinical effect and safety were similar to those whi...Continue Reading

Citations

Nov 10, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Viktoria VargaLars Thomassen
Feb 21, 2009·Stroke; a Journal of Cerebral Circulation·Yongjing SuZhenlu Zhang
Jan 16, 2010·Stroke; a Journal of Cerebral Circulation·Etsuro MoriUNKNOWN Japan Alteplase Clinical Trial II Group

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