PMID: 8589350Jan 1, 1995Paper

Thrombomodulin expression of sinusoidal endothelial cells in chronic viral hepatitis

Journal of Gastroenterology and Hepatology
M ZeniyaG Toda

Abstract

The expression of thrombomodulin on sinusoidal endothelial cells was studied using the immuno-peroxidase method and both light and electron microscopy in patients with chronic viral hepatitis (type B: four cases; type C: 28 cases). Thrombomodulin was found on sinusoidal endothelial cells, especially on the surface in both type B and type C chronic hepatitis. There was no correlation between the level of thrombomodulin expression and clinical data including serum level of transaminase, and coagulating factors. The supernatant of liver tissue homogenate obtained from the patients showed a clear 80 kDa single band by western blotting. We concluded that the expression of thrombomodulin might be related to hepatic inflammatory responses in chronic viral hepatitis.

References

Mar 1, 1986·The Journal of Experimental Medicine·P P Nawroth, D M Stern

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Citations

Sep 10, 2008·Hand : Official Journal of the American Association for Hand Surgery·Dennis S KaoHani S Matloub
Aug 30, 2012·Journal of Medical Virology·M GoeijenbierE C M van Gorp
May 17, 2014·Blood·Nelson Chao
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jacek BorawskiMichał Myśliwiec
Jan 9, 2003·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jacek BorawskiMichal Mysliwiec
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J BorawskiM Myśliwiec

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