PMID: 8960994Nov 1, 1996Paper

Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
M Shaarawy, H E Didy

Abstract

Preeclampsia has been recently suggested to be an endothelial cell disorder. This study was initiated to determine the levels of various biomarkers of endothelial damage in preeclampsia and eclampsia. Blood samples were withdrawn from 70 pregnant women in their third trimester grouped as 25 mild preeclampsia, 15 severe preeclampsia, 10 eclampsia and 20 normotensive healthy women (controls) for the determination of thrombomodulin by ELISA, PAI-1 by urokinase method and fibronectin by radial immunodiffusion. Results were statistically analyzed by Student's t-test. Circulation levels of PAI-1, thrombomodulin and fibronectin were increased with increasing severity of the disease. Thrombomodulin was the only parameter which did not change significantly in mild preeclampsia. The average percent increments in preeclampsia and eclampsia were 63%, 102% and 132%, respectively. These results demonstrate that fibronectin may be a more valuable biomarker than thrombomodulin and PAI-1 for the assessment of endothelial damage in preeclampsia and eclampsia.

References

Jul 1, 1990·Seminars in Thrombosis and Hemostasis·J BonnarB L Sheppard
Feb 1, 1990·American Journal of Obstetrics and Gynecology·C J Lockwood, J H Peters
Aug 1, 1989·American Journal of Obstetrics and Gynecology·V BallegeerD Collen
Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Dec 1, 1985·The Journal of Clinical Investigation·H Ishii, P W Majerus
Nov 1, 1988·British Journal of Haematology·N A BoothI R MacGregor
Jan 1, 1987·Acta Obstetricia Et Gynecologica Scandinavica·H O EriksenB A Jensen
Jan 1, 1995·American Journal of Obstetrics and Gynecology·S A FriedmanB M Sibai
Jun 1, 1994·British Journal of Obstetrics and Gynaecology·A HalliganJ Walshe
Sep 1, 1994·American Journal of Obstetrics and Gynecology·C D HsuD W Chan
Jul 1, 1993·American Journal of Obstetrics and Gynecology·C D HsuD W Chan
Apr 1, 1993·British Journal of Obstetrics and Gynaecology·A ReithB Bennett

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Citations

Jun 16, 2010·Archives of Gynecology and Obstetrics·Imran A SiddiquiHanan M F Al Kadri
Feb 12, 2013·Current Hypertension Reports·Vesna D Garovic, Phyllis August
Mar 24, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M ShaarawyM Sheiba
Sep 1, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S S SudN K Ganguly
Nov 28, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Luís BeloIrene Rebelo
Dec 4, 2003·Genetic Testing·Tanja HäkliSeppo Heinonen
Feb 15, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·F BretelleF Dignat-George
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Iasmina CraiciVesna D Garovic
Nov 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Yves GiguèreJean-Claude Forest
Aug 31, 2004·Journal of Thrombosis and Haemostasis : JTH·M P M De MaatC J M De Groot
Aug 27, 2009·The Journal of Obstetrics and Gynaecology Research·Seiji InoueYuji Hiramatsu
Jul 31, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Lesley J BrennanSandra T Davidge
May 25, 2015·American Journal of Obstetrics and Gynecology·Darcy R BarryThomas R Easterling
Mar 16, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tamara StampalijaSonia S Hassan
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Eva Maria RoesEric A Steegers
Sep 19, 2002·American Journal of Obstetrics and Gynecology·María Eugenia ChavarríaAlejandro Reyes
Jul 21, 2004·Atherosclerosis·Vanessa A RodieIan A Greer
Nov 22, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Füsun G VarolMuzaffer Demir
Jul 20, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Lothar HeilmannKunhard Pollow
Feb 8, 2005·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M ShaarawyI Abdel-Mohsen
Sep 16, 2000·Hypertension·A YoshidaH Kobayashi
Oct 25, 2007·Nature Clinical Practice. Nephrology·Vesna D Garovic, Suzanne R Hayman
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·C TempferC Kainz
May 2, 2002·The Journal of Biological Chemistry·Yang XiaRodney E Kellems
Jan 15, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gabriela F de LarrañagaLiliana Voto
May 13, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mary Downes GastrichTodd Rosen
Dec 15, 2016·Frontiers in Medicine·Douglas B Kell, Louise C Kenny
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Christy-Lynn M CookeSandra T Davidge
Jan 27, 2011·Seminars in Nephrology·Roxanna A Irani, Yang Xia

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