Thrombophilia in venous leg ulcers: a comparative study in early and later onset

Indian Journal of Dermatology, Venereology and Leprology
Ana M CalistruFilomena Azevedo

Abstract

Several studies found that the patients with chronic venous ulcers (CVU) have an increased prevalence of thrombophilia (44-75%), similar to that observed in deep vein thrombosis (DVT). The patients who develop CVU before their 50 th birthday appear to represent a distinct group in terms of etiology, natural history and prognosis. To analyze the nature and prevalence of thrombophilia in patients with early onset of CVU (before 50-years old) compared with a group of patients with later onset. Twenty-seven consecutive patients of each group were studied. They underwent clinical assessment and blood testing for factor V Leiden, prothrombin G20210A, methyltetrahydrofolate reductase C677T, plasminogen activator inhibitor type 1 (PAI-1) mutations, antithrombin, proteins C and S levels, and also antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant), cryoglobulins and cryoagglutinins. All the patients had at least one thrombophilia. The prevalences of single, 2 and ≥3 thrombophilias were 29.6%, 40.7% and 29.6%, respectively, in the early onset group, compared with 33.3%, 59.2% and 7.4% in the later onset group. The PAI-1 4G/4G homozygous mutation was significantly more common in patients with early onset of ul...Continue Reading

Citations

May 28, 2014·The International Journal of Lower Extremity Wounds·Paulo Ricardo CriadoRobert S Kirsner
Nov 30, 2018·British Journal of Haematology·Matthew K H TanAlun H Davies
Jan 13, 2016·Iranian Red Crescent Medical Journal·Mehri SeifoleslamiMaryam Khayyat Khameneie
Jan 24, 2020·Advances in Skin & Wound Care·Asfandyar MuftiAfsaneh Alavi

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

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