Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
L GhisdalD Abramowicz

Abstract

The aim of our study was to evaluate the prevalence of acquired thrombophilic factors in Stage V chronic kidney disease (CKD) patients according to dialysis modality, the rate of correction of these factors 1 month after renal transplantation and their impact on cardiovascular or thromboembolic events at 1 year. Three hundred and ten patients were prospectively screened for seven thrombophilic factors at transplantation; 215 of them were also assayed 1 month after. All the patients received prophylactic acetylsalicylic acid, started before transplantation. The prevalence of thrombophilic factors was significantly higher in patients under dialysis (n = 289) than in patients not yet on dialysis (n = 21) (74 versus 52.4%; P = 0.03) but was similar in haemodialysis and peritoneal dialysis patients (74.2 versus 73.2%). One month after transplantation, the global prevalence of thrombophilic factors had dropped from 74.4 to 44.7% (P < 0.001). Most thrombophilic factors had disappeared after transplantation: antithrombin deficiency: 13.5 versus 0.9%; P < 0.001, protein C deficiency: 12.1 versus 1.9%; P < 0.001, protein S deficiency: 3.7 versus 1.4%; P = 0.1, lupus anticoagulant: 37.7 versus 8.4%; P < 0.001 and antiphospholipid antibodi...Continue Reading

References

Jul 28, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Gagan KumarMilwaukee Initiative in Critical Care Outcomes Research (MICCOR) Group of Investigators
Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Birgitta SalmelaRiitta Lassila
Feb 3, 2015·Hämostaseologie·A BauerU Nowak-Göttl
Nov 22, 2014·Hemodialysis International·Chinedu NwekeDaniel Carl
Nov 25, 2015·Nature Reviews. Nephrology·Thati MadhusudhanBerend Isermann
Nov 2, 2018·Pediatric Transplantation·Margret E BockRukhmi Bhat
Sep 29, 2015·Transplantation·Sandesh ParajuliJody L Kujovich
Apr 22, 2016·Medicine·Yuh-Shin ChangRen-Long Jan
Jun 12, 2020·Hemodialysis International·Paul R J AmesFabrizio Gentile

Citations

Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F García-MartínF Saiz
Jun 1, 1990·Australian and New Zealand Journal of Medicine·W ShiC N Chesterman
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N D VaziriS Said
May 16, 1998·Transplantation·M FischerederW Land
Apr 21, 1999·Lancet·F R Rosendaal
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·K P BhatiaC D Marsden
Apr 20, 2001·The New England Journal of Medicine·U Seligsohn, A Lubetsky
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M FischerederW Land
Nov 13, 2001·Kidney International·R D FrankJ Floege
Aug 13, 2003·Kidney International·Didier DuclouxJean-Marc Chalopin
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mangalathillam R N NampooryMusthafa Al Mousawi
Apr 17, 2004·Transplantation·Jody L Kujovich
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Linda F FriedAnne Newman
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Greg A KnollMarc A Rodger
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Wendy LimJohn W Eikelboom
Jul 20, 2007·Scandinavian Journal of Immunology·S P ArdoinD S Pisetsky
Aug 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Noora S AlakulppiJarmo T Laine
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G Al-MassaraniL Camoin-Jau
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L GhisdalD Abramowicz

Related Concepts

Inherited Factor II Deficiency
Hemodialysis
Antiphospholipid Antibodies
Diagnostic Radiology Modality
Protein S Deficiency
Thrombophilia
Chronic Kidney Insufficiency
Factor V
Thrombophilia DUE TO Activated Protein C Resistance (Disorder)
Kidney

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