Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension

The Journal of Obstetrics and Gynaecology Research
Siti Z OmarSunil Bhalla

Abstract

The aim of the present study was to determine the existence or prevalence of thrombophilic markers such as Factor V Leiden, prothrombin G20210A, protein S, protein C, activated protein C and anti-thrombin in pre-eclampsia and pregnancy-induced hypertensive patients. Blood samples were collected from a total number of 124 women at the maternity unit, University of Malaya Medical Center. These included 49 patients with pre-eclampsia, 63 patients with pregnancy-induced hypertension and 12 normal pregnant women. DNA was extracted from the blood samples. Factor V Leiden (Taq I) and prothrombin G20210A (Hind III) genotyping was done on polymerase chain reaction-restriction fragment length polymorphism. Anti-thrombin activity and the concentrations of protein C, protein S and activated protein C were measured using the IL Coagulation System (Hemosil). Of the 124 subjects, one pre-eclampsia patient was homozygous for Factor V Leiden mutation but prothrombin G20210A mutation was not present in any of the subjects. The subject with Factor V Leiden mutation also had a low activated protein C resistance and a low protein S concentration. Factor V Leiden mutation is present in the Asian population and may very well serve as one of the genet...Continue Reading

References

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Citations

Nov 10, 2011·Journal of Thrombosis and Thrombolysis·Shohreh Malek-KhosraviAbbas Parsian
Jan 10, 2013·Human Reproduction Update·A J BuurmaH J Baelde
Apr 1, 2011·Pregnancy Hypertension·Serena BertozziDiego Marchesoni
May 1, 2012·The Journal of Obstetrics and Gynaecology Research·Vajira H W DissanayakeRohan W Jayasekara
Jul 30, 2010·The Journal of Obstetrics and Gynaecology Research·Qiang WeiXinghui Liu

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