Thrombophilic risk factors in epileptic children treated with valproic Acid

Pediatric Neurology
Ozlem UnalNejat Akar

Abstract

There are few reports on valproic acid related to thrombophilia. Thrombophilic risk factors were investigated in 21 children (age range, 1-13 years) diagnosed with epilepsy and newly treated with valproic acid monotherapy. None of the children had been previously treated with any anticonvulsant agent. Before starting valproic acid therapy, homocysteine, lipoprotein(a), factor VIII, factor IX, protein C, protein S, antithrombin III levels, and activated protein C resistance levels were evaluated in all patients, with repeat evaluation after 9 months or 1 year of the therapy. Thrombosis gene mutations (factor V Leiden and prothrombin G20210A) were also evaluated in all patients before therapy. There was statistically significant elevation in lipoprotein(a) levels and reduction in fibrinogen levels after treatment. Reduction in protein C levels and elevation in homocysteine levels were also observed, but without statistical significance. Before therapy, no thrombotic event had occurred, despite thrombotic risk factors in some patients. Valproic acid can increase lipoprotein(a) and decrease fibrinogen, which may increase the risk of stroke or other thrombotic events. No clinical adverse effects resulted from changes in the levels o...Continue Reading

References

Jan 1, 1992·Epilepsia·W KreuzI Scharrer
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Jun 1, 1997·Journal of Paediatrics and Child Health·A VerrottiF Chiarelli
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Apr 1, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A MerouaniP Robitaille
Apr 19, 2000·Acta Neurologica Scandinavica·T ApelandO Kristensen
Aug 30, 2000·Epilepsy Research·A VerrottiF Chiarelli
Oct 9, 2002·Neuropediatrics·M C BanerjeaA H Sutor

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Citations

Mar 13, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A VerrottiG Coppola
Jun 13, 2009·Pediatric Neurology·Giuseppe LippiMassimo Franchini
Jun 25, 2013·Clinical Biochemistry·Radu M Nanau, Manuela G Neuman
Oct 25, 2014·Journal of Child Neurology·Reham M El-FarahatyBothina Mohammed Hasaneen
May 18, 2010·Journal of Clinical Psychopharmacology·Ravindra SrinivasarajuSuresh Bada Math

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