Thrombophilic states

Handbook of Clinical Neurology
Ida MartinelliPaolo Bucciarelli

Abstract

Cerebral venous sinus thrombosis (CVST) is a rare life-threatening disease with an estimated annual incidence of three to four cases per million in adults and seven cases per million in neonates. Brain tumors, cerebral infections or traumas, oral contraceptive use, pregnancy, and puerperium are established risk factors for CVST but in 15-20% of patients the disease is apparently unprovoked, i.e., occurring in the absence of predisposing factors. In the last decade there has been increasing evidence that early diagnosis and anticoagulant treatment reduce morbidity of CVST and improve survival. However, the optimal duration of anticoagulant treatment is not well established, because limited information is available on the rate of CVST recurrence after anticoagulant discontinuation. Thrombophilia is a hypercoagulable state leading to a thrombotic tendency, and young patients with CVST, either provoked or unprovoked, deserve investigation. Thrombophilic abnormalities can be inherited (deficiency of the natural anticoagulant proteins antithrombin, protein C, or protein S, mutations in the factor V gene (factor V Leiden) or prothrombin gene (prothrombin G20210A)), acquired (antiphospholipid antibodies), or "mixed," i.e., either conge...Continue Reading

Citations

Jun 16, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·A GirolamiB Girolami
Aug 15, 2014·Journal of Thrombosis and Thrombolysis·Darina KohoutovaJan Bures
Sep 29, 2015·Transplantation·Sandesh ParajuliJody L Kujovich
May 26, 2017·The Journal of Obstetrics and Gynaecology Research·Evgeny ReshetnikovMikhail Churnosov

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