Thrombopoietin and its splicing variants: structure and functions in thrombopoiesis and beyond.

Biochimica Et Biophysica Acta
Roberto Marcucci, Maurizio Romano

Abstract

Since its cloning in 1994, several studies have reported that thrombopoietin (THPO) presents several alternative splicing products that differ from the full-length protein in its 5' UTR, N- or C-terminal regions. Most of these splice variants are evolutionarily conserved and have been detected in different tissues as well as in cell lines. Although the possible functions of the THPO isoforms are still elusive, different clues link them to the peculiar mechanism that regulates THPO production. Moreover, novel fields to explore possible roles of the THPO variants are opened by observations that this hormone can influence the formation of hematopoietic progenitors and its expression occurs in some tumors as well as in tissues not directly related to the thrombopoiesis. In this review, we summarize the structure and functions of THPO through the published evidence on its splicing isoforms and discuss about their involvement with physiopathologic phenomena.

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Citations

Aug 12, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Qila SaJane L Hoover-Plow
Jan 21, 2009·Nucleic Acids Research·Roberto MarcucciFrancisco E Baralle
Nov 10, 2013·International Journal of Cell Biology·Maurizio RomanoDiana Baralle
Aug 14, 2012·Proteomics·Miroslava Stastna, Jennifer E Van Eyk
May 4, 2017·International Journal of Cell Biology·Samaher BesbesMassoud Mirshahi

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