Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases.

Mediators of Inflammation
E LupiaG Montrucchio

Abstract

Thrombopoietin (TPO) is a humoral growth factor originally identified for its ability to stimulate the proliferation and differentiation of megakaryocytes. In addition to its actions on thrombopoiesis, TPO directly modulates the homeostatic potential of mature platelets by influencing their response to several stimuli. In particular, TPO does not induce platelet aggregation per se but is able to enhance platelet aggregation in response to different agonists ("priming effect"). Our research group was actively involved, in the last years, in characterizing the effects of TPO in several human critical diseases. In particular, we found that TPO enhances platelet activation and monocyte-platelet interaction in patients with unstable angina, chronic cigarette smokers, and patients with burn injury and burn injury complicated with sepsis. Moreover, we showed that TPO negatively modulates myocardial contractility by stimulating its receptor c-Mpl on cardiomyocytes and the subsequent production of NO, and it mediates the cardiodepressant activity exerted in vitro by serum of septic shock patients by cooperating with TNF-α and IL-1β. This paper will summarize the most recent results obtained by our research group on the pathogenic role o...Continue Reading

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Citations

Jan 18, 2014·Diabetes & Metabolism·E MauryJ Bass
Aug 13, 2015·Intensive Care Medicine·Luca PigozziMaurizio Cecconi
Oct 21, 2017·International Journal of Molecular Sciences·Elisabetta GrecoGiuseppe Montrucchio
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Daniel J ConklinAruni Bhatnagar
Oct 30, 2015·Science Translational Medicine·Li LiJoel T Dudley
Mar 18, 2020·Neurological Research·Li DuLinlin Yin
Feb 9, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Salvatore Di SommaGiuseppe Lippi
Jun 3, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Elisabetta SegreEnrico Lupia
Aug 6, 2019·Frontiers in Immunology·Alice AssingerJulie Rayes
Mar 3, 2020·Frontiers in Genetics·Pratik P VikheDerek W Hood
Dec 1, 2019·Journal of Clinical Medicine·Laura Pletsch-BorbaTilman Kühn
Oct 21, 2020·Redox Biology·Juan WangCharles Ansong

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Methods Mentioned

BETA
antisense oligonucleotides
ELISA
flow cytometry

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