PMID: 9432045Jan 31, 1998Paper

Thrombopoietin measurement in thrombocytosis: dysregulation and lack of feedback inhibition in essential thrombocythaemia

British Journal of Haematology
L PitcherA Rentoul

Abstract

Essential thrombocythaemia (ET), a myeloproliferative disorder (MPD) manifested by excessive platelet production, lacks a specific diagnostic test to facilitate differentiation from other thrombocytoses. We studied thrombopoietin (TPO) levels in 41 patients with thrombocytosis: 25 ET patients, eight with other MPD, and eight with reactive thrombocytosis. Mean age and platelet counts for these groups were comparable. TPO levels for 96 healthy individuals provided a reference range for normal. The majority of ET patients (19/25 or 76%) had normal TPO levels. No patient with ET had a TPO level below 75 pg/ml, compared with 57% of healthy donors and 8/16 (50%) patients with other thrombocytoses (P<0.05). TPO levels in ET are not appropriately down-regulated, as occurs with cytokines relevant to other MPD. In thrombocytosis, a TPO level <75 pg/ml indicates that ET is unlikely.

Citations

Jan 20, 2000·Baillière's Clinical Haematology·R Kralovics, J T Prchal
Jun 13, 2002·British Journal of Haematology·Claire N Harrison
Aug 24, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·F HeitsW Jelkmann
Apr 29, 2000·Current Opinion in Hematology·W VerbeekG Brittinger
Feb 14, 2003·Mayo Clinic Proceedings·Ayalew Tefferi
Oct 16, 1999·The Journal of Laboratory and Clinical Medicine·H C HsuS Y Wang
Apr 22, 2016·Pediatric Blood & Cancer·Nya D NelsonAlison A Bertuch
Aug 13, 2002·Hematology·Sema KarakuşSemra V Dündar
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·W Jelkmann
Jan 20, 2000·Baillière's Clinical Haematology·T C Pearson

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