Thromboprophylaxis: balancing evidence and experience during the COVID-19 pandemic

Journal of Thrombosis and Thrombolysis
Benjamin MarchandotOlivier Morel

Abstract

A common and potent consideration has recently entered the landscape of the novel coronavirus disease of 2019 (COVID-19): venous thromboembolism (VTE). COVID-19 has been associated to a distinctive related coagulopathy that shows unique characteristics. The research community has risen to the challenges posed by this « evolving COVID-19 coagulopathy » and has made unprecedented efforts to promptly address its distinct characteristics. In such difficult time, both national and international societies of thrombosis and hemostasis released prompt and timely responses to guide recognition and management of COVID-19-related coagulopathy. However, latest guidelines released by the international Society on Thrombosis and Haemostasis (ISTH) on May 27, 2020, followed the American College of Chest Physicians (CHEST) on June 2, 2020 showed some discrepancies regarding thromboprophylaxis use. In this forum article, we would like to offer an updated focus on thromboprophylaxis with current incidence of VTE in ICU and non-ICU patients according to recent published studies; highlight the main differences regarding ISTH and CHEST guidelines; summarize and describe which are the key ongoing RCTs testing different anticoagulation strategies in p...Continue Reading

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Citations

Nov 18, 2020·Journal of Thrombosis and Thrombolysis·Kensuke MatsushitaOlivier Morel
Dec 31, 2020·Journal of Clinical Medicine·Antonin TrimailleOlivier Morel
Dec 9, 2020·Journal of Vascular Surgery·John J KanitraElango Edhayan
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Sep 30, 2021·Current Hematologic Malignancy Reports·Tiziano Barbui, Valerio De Stefano

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Clinical Trials Mentioned

NCT04362085
NCT04367831
NCT04445935
NCT04357730
NCT04359277
NCT04344756
NCT04373707
NCT04394377
NCT04351724
NCT04416048

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