Thromboprophylaxis following major skeletal trauma: a systematic review

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
Toby O SmithCaroline B Hing

Abstract

Venous thromboembolic disease following skeletal polytrauma is a major issue for trauma surgeons, but there is no consensus of opinion regarding the optimal form of prophylaxis. The purpose of this paper was to compare the incidence of venous thromboembolic events (VTE) after major skeletal trauma managed with different prophylactic methods and their combinations. A search of AMED, CINAHL, Cochrane Library, EMBASE and MEDLINE databases was performed from their inception to July 2010. A search of unpublished literature databases was undertaken. All randomised controlled trials assessing the incidence of VTE events between two or more forms of thromboprophylaxis for patient following major skeletal trauma were included. Two reviewers independently identified all eligible articles, extracted the data, and critically appraised all included publications using the Critical Appraisal Skills Programme tool. A total of 11 papers were identified. The findings of this study suggest that low molecular weight heparin (LMWH) may be superior to low dose heparin (LDH), and that LMWH should be used in addition to mechanical prophylaxis measures in patients following major skeletal trauma. There is limited evidence for the use of electrostimulat...Continue Reading

References

Jan 1, 1992·The Journal of Trauma·M M KnudsonD W McCrory
Nov 1, 1995·The Journal of Bone and Joint Surgery. American Volume·K D MontgomeryD L Helfet
Dec 15, 1994·The New England Journal of Medicine·W H GeertsJ P Szalai
Sep 1, 1994·The Journal of Trauma·M M KnudsonJ Megerman
Aug 1, 1996·Clinical Orthopaedics and Related Research·K D MontgomeryD L Helfet
Sep 1, 1996·The Journal of Trauma·M M KnudsonS Shackleford
Jan 1, 1997·The Journal of Trauma·L J GreenfieldJ Cho
Feb 28, 2001·Journal of the American College of Surgeons·S H NorwoodJ W McLarty
Jun 14, 2001·Archives of Internal Medicine·J AttiaW H Geerts
Jul 14, 2001·The Journal of Bone and Joint Surgery. American Volume·J P StannardJ E Alonso
Sep 8, 2001·Critical Care Medicine·A F Shorr, A S Ramage
Dec 12, 2001·The Journal of Trauma·G V RussellM L Chip Routt
Mar 20, 2002·The Journal of Trauma·Mark D CipolleMichael D Pasquale
Dec 13, 2002·The Journal of Trauma·Richard P SharpeC William Schwab
Nov 5, 2003·The British Journal of Surgery·E GinzburgUNKNOWN Miami Deep Vein Thrombosis Study Group
Mar 2, 2005·The Journal of Bone and Joint Surgery. British Volume·N SteeleM H Morse
Jun 24, 2005·The Journal of Bone and Joint Surgery. British Volume·J P StannardJ E Alonso
Jul 29, 2005·The Journal of Bone and Joint Surgery. British Volume·S FuchsC Chylarecki
Feb 3, 2006·The Journal of Bone and Joint Surgery. American Volume·James P StannardJorge E Alonso
May 27, 2006·QJM : Monthly Journal of the Association of Physicians·S GoodacreS Thomas
Jun 15, 2006·Pathophysiology of Haemostasis and Thrombosis·Davide Imberti, Walter Ageno
Mar 21, 2008·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Zahra TejaniJane Goodman
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
May 1, 2010·Orthopaedic Surgery·UNKNOWN Chinese Orthopaedic Association

❮ Previous
Next ❯

Citations

Apr 2, 2013·The Cochrane Database of Systematic Reviews·Luis M BarreraCarlos Hernando Morales Uribe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.