Thromboprophylaxis in the End-of-Life Cancer Care: The Update

Cancers
Ewa Zabrocka, Ewa Sierko

Abstract

Cancer patients are at increased risk for venous thromboembolism (VTE), which further increases with advanced stages of malignancy, prolonged immobilization, or prior history of thrombosis. To reduce VTE-related mortality, many official guidelines encourage the use of thromboprophylaxis (TPX) in cancer patients in certain situations, e.g., during chemotherapy or in the perioperative period. TPX in the end-of-life care, however, remains controversial. Most recommendations on VTE prophylaxis in cancer patients are based on the outcomes of clinical trials that excluded patients under palliative or hospice care. This translates to the paucity of official guidelines on TPX dedicated to this group of patients. The problem should not be underestimated as VTE is known to be associated with symptoms adversely impacting the quality of life (QoL), i.e., limb or chest pain, dyspnea, hemoptysis. In end-of-life care, where the assurance of the best possible QoL should be the highest priority, VTE prophylaxis may eliminate the symptom burden related to thrombosis. However, large randomized studies determining the benefits and risks profiles of TPX in patients nearing the end of life are lacking. This review summarized available data on TPX in...Continue Reading

References

Mar 31, 1998·Palliative Medicine·M J Johnson, K Sherry
Jun 23, 1999·Clinical Oncology : a Journal of the Royal College of Radiologists·M J JohnsonJ Paul
Mar 28, 2006·BMJ : British Medical Journal·John C Chambers
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·M MonrealUNKNOWN Riete Investigators
Oct 18, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Catherine WeberGilbert B Zulian
Jan 17, 2008·The American Journal of Hospice & Palliative Care·Katharina A KiernerHerbert H Watzke
Sep 6, 2008·Palliative Medicine·S I R NobleI G Finlay
Mar 17, 2009·Best Practice & Research. Clinical Haematology·Ted Wun, Richard H White
Mar 3, 2010·Journal of Palliative Medicine·John BrysonCamilla Zimmermann
Jun 24, 2010·Cancer·Holly M HolmesJames S Goodwin
Sep 11, 2010·Blood·Cihan AyIngrid Pabinger
Dec 15, 2010·Journal of Pain and Symptom Management·Sandra LegaultJosé Pereira
Feb 12, 2011·Palliative Medicine·Suzie GillonMiriam J Johnson
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MandalàUNKNOWN ESMO Guidelines Working Group
Nov 29, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Verena GartnerUNKNOWN AUPACS group
Aug 3, 2013·Blood·Jasmijn F TimpSuzanne C Cannegieter
Dec 18, 2013·Journal of Pain and Symptom Management·Miriam J JohnsonSimon I R Noble
Jun 27, 2014·Therapeutics and Clinical Risk Management·Grigoris T GerotziafasIsmail Elalamy
Aug 8, 2014·Journal of Palliative Medicine·Joan M TenoVincent Mor
Mar 6, 2015·Thrombosis and Haemostasis·Sam SchulmanJörg Kreuzer
Sep 27, 2015·Journal of Thrombosis and Haemostasis : JTH·G AgnelliT Yamabe
Dec 31, 2016·Journal of Thrombosis and Haemostasis : JTH·B TardyL Bertoletti
Apr 21, 2017·The Oncologist·Chiara Alessandra CellaSabino De Placido
Jun 6, 2017·Journal of Palliative Medicine·Christina A KowalewskaJon P Furuno
Dec 1, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cristhiam M Rojas-Hernandez
Mar 10, 2018·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Ewa ZabrockaEwa Sierko
Aug 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nigel S KeyAnna Falanga
Sep 8, 2019·The Lancet Oncology·Dominique FargeUNKNOWN International Initiative on Thrombosis and Cancer (ITAC) advisory panel

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
light reflection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.