Thrombosis and thromboembolism related to COVID-19: A clarion call for obtaining solid estimates from large-scale multicenter data.

Research and Practice in Thrombosis and Haemostasis
Stefano BarcoCORE‐THROMBOSIS Investigators

Abstract

The clinical spectrum of coronavirus disease 2019 (COVID-19) is wide, ranging from minor, nonspecific symptoms to severe pneumonia, acute respiratory distress syndrome, multiorgan involvement, and shock. In severe cases, the acute systemic inflammatory response, coagulation activation, and diffuse endothelial damage may, in combination with hypoxia, immobilization, and underlying risk factors, result in potentially life-threatening venous and arterial thrombotic events. The first data from single-center retrospective studies suggest that thrombotic events are a key aspect of COVID-19-associated morbidity and mortality. We have planned and will be launching the COvid REgistry on THROMBOSIS (CORE-THROMBOSIS), a large online registry of previously or currently hospitalized patients with COVID-19. The study aims to (i) determine the rate of acute thrombotic events in consecutive hospitalized patients with coronavirus (COVID-19); (ii) investigate the current use and trends in thromboprophylaxis regimens; and (iii) describe the use of imaging tests for the detection of cardiovascular events in patients with COVID-19.

References

Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Mar 5, 2020·American Journal of Hematology·Bingwen Eugene FanKiat Hoe Ong
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Apr 9, 2020·The New England Journal of Medicine·Yan ZhangShuyang Zhang
Apr 18, 2020·Journal of Thrombosis and Haemostasis : JTH·Jean M Connors, Jerrold H Levy
May 1, 2020·Thrombosis Research·Corrado LodigianiUNKNOWN Humanitas COVID-19 Task Force
May 6, 2020·Intensive Care Medicine·Julie HelmsUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sep

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Citations

Aug 25, 2020·Research and Practice in Thrombosis and Haemostasis·Rachel P RosovskyLisa Baumann Kreuziger
Nov 21, 2020·BMC Gastroenterology·Roham BorazjaniZhila Rahmanian
Sep 23, 2020·European Journal of Internal Medicine·Loris RonconStavros V Konstantinides
Jun 25, 2020·VASA. Zeitschrift für Gefässkrankheiten·Stefano BarcoNils Kucher

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Software Mentioned

COvid REgistry
CORE
THROMBOSIS

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