Thrombosis associated with procainamide-induced lupus anticoagulant

Acta Haematologica
A F List, D C Doll

Abstract

A predisposition to thrombosis in patients with procainamide-induced lupus anticoagulants is previously unrecognized. We describe two patients treated with procainamide who experienced acute thromboembolic events temporally associated with development of the lupus anticoagulant. One patient had a deep venous thrombosis and pulmonary embolism, while the other patient had a cerebrovascular accident. In both patients, coagulation parameters corrected with interruption of procainamide therapy. We suggest that thrombosis may complicate treatment with procainamide in patients who develop the lupus anticoagulant.

Citations

Dec 14, 2011·Current Rheumatology Reports·Jeffrey S Dlott, Robert A S Roubey

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