Thrombosis in atherogenesis

Critical Reviews in Oncology/hematology
K L Kaplan, A Bini


This review addresses the question of the involvement of fibrin in the development of atherosclerotic plaques. Numerous studies in the older literature demonstrated the presence of fibrinogen and/or fibrin in plaques, but the techniques that were available (mainly immunochemistry and immunohistochemistry with polyclonal antifibrinogen antibodies) did not clearly distinguish fibrinogen from fibrin or fibrinogen/fibrin degradation products. Some of these studies suggested that the fibrinogen-related protein within lesions resulted from incorporation of thrombi into lesions, while other studies suggested that fibrinogen itself entered the vessel wall. Newer studies by the authors and collaborators used specific antibodies for various fibrinopeptides to quantitate fibrinogen, fibrin I, fibrin II, and fragment X in thrombi and different histologic types of plaques. These studies showed that normal aortas contained fibrinogen and that fatty and fibrous plaques contained fibrinogen, fibrin I, and fibrin II, while complicated plaques contained fibrin II and fragment X, indicating a progression from fibrinogen to fibrin and fibrinogen/fibrin degradation products in parallel with increasing severity of the lesions. Later studies by the a...Continue Reading


Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C R MinickW Insull
Jan 1, 1979·Tissue & Cell·J L KadishJ Folkman
Nov 24, 1977·Nature·W B Shelley, L Juhlin
Jan 1, 1977·The Journal of Experimental Medicine·L A Sherman, J Lee
Jan 1, 1987·The Journal of Clinical Investigation·J A RibesD D Wagner
Oct 1, 1986·The Journal of Clinical Investigation·D C AltieriA M Capitanio
Jan 1, 1985·The Journal of Clinical Investigation·E DejanaG Marguerie
Dec 8, 1972·Annals of the New York Academy of Sciences·K LakiJ Farrell
Nov 1, 1972·Atherosclerosis·J R Shainoff, I H Page
Apr 1, 1969·The Journal of Pathology·N Woolf, K C Carstairs
Jan 1, 1984·Haemostasis·J W Shands
Feb 1, 1983·The Journal of Experimental Medicine·N Hogg
Feb 1, 1982·Atherosclerosis·E B Smith, E M Staples
May 1, 1980·The Journal of Experimental Medicine·G A Levy, T S Edgington
Jul 1, 1952·The Journal of Pathology and Bacteriology·T CRAWFORD, C I LEVENE
Jan 1, 1948·The Journal of Pathology and Bacteriology·J B DUGUID


May 10, 2000·Mechanisms of Ageing and Development·A Ramirez BoscaJ Miquel
Mar 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J KreuzerE von Hodenberg
Dec 4, 1992·Annals of the New York Academy of Sciences·A Bini, B Kudryk
Jan 17, 1995·Annals of the New York Academy of Sciences·A Bini, B Kudryk

Related Concepts

Fibrin-fibrinogen-related antigen
Endothelium, Vascular
Antithrombin I
Fibrin split products

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.