Thrombosis: Novel nanomedical concepts of diagnosis and treatment

World Journal of Cardiology
Iwona Cicha

Abstract

Intravascular thrombosis, a critical pathophysiological feature of many cardiovascular disorders, leads to the formation of life-threatening obstructive blood clots within the vessels. Rapid recanalization of occluded vessels is essential for the patients' outcome, but the currently available systemic fibrinolytic therapy is associated with low efficacy and tremendous side effects. Additionally, many patients are ineligible for systemic thrombolytic therapy, either due to delayed admission to the hospital after symptom onset, or because of recent surgery, or bleeding. In order to improve the treatment efficacy and to limit the risk of hemorrhagic complications, both precise imaging of the affected vascular regions, and the localized application of fibrinolytic agents, are required. Recent years have brought about considerable advances in nanomedical approaches to thrombosis. Although these thrombus-targeting imaging agents and nanotherapies are not yet implemented in humans, substantial amount of successful in vivo applications have been reported, including animal models of stroke, acute arterial thrombosis, and pulmonary embolism. It is evident that the future progress in diagnosis and treatment of thrombosis will be closely b...Continue Reading

Citations

Feb 16, 2017·Therapeutic Advances in Cardiovascular Disease·Virna Margarita Martín GiménezWalter Manucha
Jun 12, 2018·Biomicrofluidics·Michael T GriffinDavid N Ku
May 12, 2021·Nanomedicine·Vishnu PriyaMadaswamy S Muthu
Jul 11, 2021·The Journal of Pharmacy and Pharmacology·Tahereh Zadeh Mehrizi, Sedigheh Amini Kafiabad
Oct 30, 2021·ACS Nano·Bilal HussainReza Abdi

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