PMID: 11344632May 10, 2001Paper

Thrombotic complications in patients with malignant diseases

Vnitr̆ní lékar̆ství
D Karetová

Abstract

The incidence of thromboembolic disease (TED) in malignant diseases is high and is often the cause of death in these patients. The most important thrombogenic factors are changes of the coagulation system, venostasis, changes in the function and structure of the endothelium and the influence of specific anti-tumour therapy. The most frequent clinical manifestation is phlebothrombosis of the lower extremity. Diagnostic procedures in detection of thrombosis do not differ fundamentally from standard procedures (clinical examination, duplex sonography, phlebography, possibly pulmonary scintigraphy). More intensive prophylaxis of TED is necessary under certain conditions (surgical treatment, immobilization, chemotherapy). Therapeutic patterns with heparins, possibly thrombolytics, are common but subsequent anticoagulation treatment must be provided as long as the active stage of the neoplastic disease persists, in particular if the patient is treated with cytostatics. When anticoagulation treatment is contraindicated and there is a general favourable prognosis, implantation of caval filters is an adequate provision. New findings indicate the possible anti-tumourous action of low-molecular heparins, but these are only initial observa...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
S-M Maksan, T Schmitz-Rixen
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Nadia HindiEnrique Espinosa
Zeitschrift für die gesamte innere Medizin und ihre Grenzgebiete
F Heinrich
Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
Lin-tao Liu, Bao-tong Ma
Lancet
Marc SchindewolfWolf-Henning Boehncke
© 2021 Meta ULC. All rights reserved