Thrombotic complications in von Willebrand disease

Hematology
Massimo Franchini

Abstract

Thrombotic events occur rarely in patients with von Willebrand disease (VWD). In this review we analyze the data reported in the literature, selected through a PubMed search, on thrombotic complications in VWD patients. On the basis of this analysis, we conclude that thrombotic complications in VWD patients often have a multi-factorial pathogenesis resulting from a complex interaction between acquired (coagulation factor replacement, surgery, cardiovascular risk factors) and/or inherited (thrombophilic gene mutations) prothrombotic risk factors.

References

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Jan 14, 2004·Journal of Thrombosis and Haemostasis : JTH·Z M Ruggeri
Jul 23, 2004·Thrombosis and Haemostasis·Massimo Franchini
Jul 23, 2004·Thrombosis and Haemostasis·Karin van DijkH Marijke van den Berg
Aug 13, 2004·The New England Journal of Medicine·Pier Mannuccio Mannucci
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Jan 22, 2005·Annual Review of Medicine·J Evan Sadler

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