Abstract
Asparaginase is essential in the treatment of lymphoproliferative malignancies, but it is associated with several side effects. The objective of this study was to compare asparaginase-induced alterations of the coagulation inhibitors and the impact on central line-associated thrombosis in children treated according to 2 different asparaginase regimens. The study enrolled 30 children treated for acute lymphoblastic leukemia, and they were divided into 2 groups with respect to asparaginase preparation and protocol (NOPHO ALL-1992 versus NOPHO ALL-2000). The coagulation inhibitors antithrombin, protein C, and proteins S were measured prior to and during asparaginase therapy, and incidence of central line-associated thromboses was compared to evaluate the protocols' thrombogenicity. Thirteen children received Erwinia asparaginase and 17 children received E. coli asparaginase. Independent of protocol, the coagulation inhibitors were significantly reduced during asparaginase therapy (p < .001), and central line-associated thromboses were frequent. Four children developed thrombosis in the course of asparaginase therapy, and there was a correlation between asparaginase-induced fall of antithrombin and occurrence of new thromboses (p =...Continue Reading
References
Jan 1, 1990·Medical and Pediatric Oncology·O B EdenS Richards
Jun 1, 1982·The Journal of Pediatrics·J R PriestP F Coccia
Jun 1, 1982·The Journal of Pediatrics·J R PriestJ R Edson
Jan 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M AndrewL Mitchell
Jan 1, 1995·International Journal of Clinical & Laboratory Research·U Nowak-GöttlH Jürgens
Oct 1, 1996·British Journal of Haematology·U Nowak-GöttlJ Boos
Aug 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J BoosH Jürgens
Apr 15, 1997·Thrombosis Research·M De CiccoV Testa
Oct 13, 1998·Critical Reviews in Oncology/hematology·H J Müller, J Boos
Feb 27, 1999·Leukemia & Lymphoma·S R AlbertsT E Witzig
Oct 25, 2000·Pediatric Research·J DötschH G Dörr
Feb 24, 2001·Leukemia·G GustafssonU M Saarinen-Pihkala
Oct 24, 2001·Thrombosis Research·U Nowak-GöttlR Junker
Oct 27, 2001·British Journal of Clinical Pharmacology·B K AlbertsenK Schmiegelow
May 2, 2002·Medical and Pediatric Oncology·Ellen RuudFinn Wesenberg
Jan 9, 2003·Cancer·Lesley G MitchellUNKNOWN Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase Group (PARKAA)
Jul 31, 2003·Thrombosis and Haemostasis·Lesley MitchellDavid Mikulis
Dec 1, 1953·The Journal of Experimental Medicine·J G KIDD
Jul 1, 1963·The Journal of Experimental Medicine·J D BROOME
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melina Verso, Giancarlo Agnelli
Dec 20, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G GattaUNKNOWN EUROCARE Working Group
Apr 2, 2004·Leukemia·L J HakC-H Pui
Apr 3, 2004·British Journal of Haematology·João Paulo Vieira Pinheiro, Joachim Boos
Citations
Jan 1, 2009·International Journal of General Medicine·Yan LiuNing Xu
Mar 17, 2009·Best Practice & Research. Clinical Haematology·Ulrike Nowak-GöttlLesley G Mitchell
Apr 29, 2009·Acta Paediatrica·Sólveig HafsteinsdóttirAsgeir Haraldsson
Jan 16, 2008·Journal of Thrombosis and Haemostasis : JTH·S KuhleL G Mitchell
Jun 27, 2007·British Journal of Haematology·Kajsa PaulssonBertil Johansson
Oct 1, 2013·Thrombosis Research·Xiushuai DongJinghua Wang
Mar 27, 2010·Blood·Lesley MitchellUlrike Nowak-Göttl
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Reineke A SchootCornelia H van Ommen
Aug 26, 2006·The Journal of Biological Chemistry·Rachel B ReinertTracy G Anthony
Feb 7, 2018·Thrombosis Research·B T Samuelson Bannow, B A Konkle
Sep 3, 2021·Seminars in Thrombosis and Hemostasis·Rasmus Søgaard HansenAnne-Mette Hvas