Thrombotic microangiopathies

Seminars in Arthritis and Rheumatism
Michael H Rosove

Abstract

To review the clinical features and pathophysiologic mechanisms of the thrombotic microangiopathies (TMAs) including acquired and congenital thrombotic thrombocytopenic purpura (TTP), Shiga toxin-induced and atypical (non-Shiga toxin-induced) hemolytic uremic syndrome (HUS), and the TMAs associated with pregnancy, drugs, and organ transplantation. PubMed Medline was used to identify articles published from 2000 to July 2013 using the following key words: thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, Shiga toxin, ADAMTS13, and eculizumab. Articles in languages other than English, papers available in abstract form only, and nearly all single case reports were excluded. Small series, reports from registries and study groups, reviews, guidelines, and articles concerning pathophysiology and therapy were preferentially considered. Impaired post-secretion processing of unusually large von Willebrand multimers due to deficiency of ADAMTS13 (IgG antibodies or congenital), dysregulation of the alternative complement pathway (mutations and/or specific antibodies), and endothelial injury are pathophysiologic mechanisms involved in the TMAs. Acquired and congenital TTP are due primarily to severe ADAMTS13 deficiency, atypi...Continue Reading

References

Dec 22, 1977·The New England Journal of Medicine·J J Byrnes, M Khurana
Aug 1, 1978·The American Journal of Medicine·R C BoneM Amare
Apr 20, 1979·JAMA : the Journal of the American Medical Association·L R BerkowitzP M Blatt
Apr 27, 1978·The New England Journal of Medicine·F KosterR C Williams
Jun 1, 1975·Annals of Internal Medicine·A KadriN K de Leeuw
Jan 1, 1992·Nihon rinsho. Japanese journal of clinical medicine·S ShirakawaM Tanigawa
Jul 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H TsukaharaS Fujisawa
Jul 1, 1966·Annals of Internal Medicine·T N James, R W Monto
Feb 11, 1982·The New England Journal of Medicine·L W Hoyer
Feb 13, 1999·American Journal of Obstetrics and Gynecology·C W RedmanI L Sargent
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joel C ReynoldsKevin C Abbott
Jan 5, 2005·Trends in Immunology·Sonia Jancar, Mariano Sánchez Crespo
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Marina Noris, Giuseppe Remuzzi
Mar 19, 2005·Blood·Gallia G LevyDavid Ginsburg
Apr 15, 2005·Emerging Infectious Diseases·Josefa M RangelDavid L Swerdlow
Jun 29, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Corey CutlerJoseph H Antin
Aug 24, 2005·British Journal of Haematology·M C Kappers-KlunneA Brand
Oct 26, 2005·Clinical Nephrology·K FujisakiM Iida
Jan 20, 2006·Transplantation·Ramsey R HachemElbert P Trulock
Apr 20, 2006·Blood·Jessica CaprioliUNKNOWN International Registry of Recurrent and Familial HUS/TTP
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·N TurnerJ Moake
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·M C PickeringM Botto
Aug 8, 2006·Journal of Thrombosis and Haemostasis : JTH·J E SadlerUNKNOWN Working Party on von Willebrand Disease Classification
Sep 14, 2006·British Medical Bulletin·David KavanaghAnna Richards
Sep 14, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hassane IzzedineGilbert Deray
Oct 13, 2006·American Journal of Hematology·Theresa L WernerGeorge M Rodgers

❮ Previous
Next ❯

Citations

Jan 15, 2016·Thrombosis and Haemostasis·Bálint MikesZoltán Prohászka
Apr 27, 2016·Hematology/oncology Clinics of North America·Tahir MehmoodJeffrey L Winters
Sep 26, 2015·Seminars in Hematology·Photis Beris, Véronique Picard
Feb 26, 2016·American Journal of Hematology·Bashiar ThejeelAinslie M Hildebrand
Jul 18, 2018·Histopathology·Frederick PfisterMaike Büttner-Herold
Jun 4, 2015·Journal of the American Society of Nephrology : JASN·Luise ErpenbeckDenisa D Wagner
Dec 8, 2015·Hematology·James N GeorgeJennifer J McIntosh
Apr 4, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kibriya FidanOguz Soylemezoglu
May 17, 2017·CEN Case Reports·Haruomi NishioMotoko Yanagita
May 28, 2019·Néphrologie & thérapeutique·Mathilde LemoineDominique Guerrot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Related Papers

The Journal of the Association of Physicians of India
Mrinal M PatnaikK M Algotar
Current Opinion in Nephrology and Hypertension
Peter F ZipfelChristine Skerka
© 2021 Meta ULC. All rights reserved