Thrombotic microangiopathy and the antiphospholipid syndrome

Lupus
S J A JohnsenR Omdal

Abstract

The antiphospholipid syndrome (APS) comprises the association between vascular thrombosis, including microthrombosis, pregnancy morbidity and the coexistence of anti-phospholipid antibodies. Thrombotic microangiopathy (TMA) can be one of the manifestations of the APS and may involve any organ. This feature of the APS is probably less recognized by clinical doctors than venous thrombosis and recurrent abortions. This case report presents a patient who developed a widespread TMA with renal failure, gastric mucosa ulceration, urinary bladder ulcerations and a finger necrosis as part of the APS.

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Citations

Jun 30, 2012·Autoimmunity Reviews·Olga L QuinteroJuan-Manuel Anaya
Jun 1, 2012·Journal of Neuroimmunology·Shin-ichi TokushigeHideji Hashida
Jun 24, 2017·Blood·Douglas B Cines, Lisa D Levine
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Jan 24, 2020·Advances in Skin & Wound Care·Asfandyar MuftiAfsaneh Alavi
Jul 3, 2021·International Journal of Molecular Sciences·Kun-Hua TuHuang-Yu Yang
Apr 2, 2021·GE Portuguese Journal of Gastroenterology·Ana Luísa LourençoVera Bernardino

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.