Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia

Nephrology
Kresimir GalesicMira Scukanec-Spoljar

Abstract

The association of interferon (IFN) therapy with haemolytic uraemic syndrome in patients with chronic myeloid leukaemia (CML) has been reported infrequently. The pathogenesis of the renal lesion in such cases remains unclear. We report the case of a patient with chronic myeloid leukaemia who developed nephrotic syndrome and renal failure while being treated with hydroxyurea and IFN-alpha. Renal biopsy showed features of chronic thrombotic microangiopathy. The discontinuation of IFN-alpha, and a prompt institution of plasmapheresis and steroids resulted in improvement of the nephrotic syndrome and renal function. These findings suggest that long-term IFN-alpha therapy can induce thrombotic microangiopathy and haemolytic uraemic syndrome in patients with chronic myeloid leukaemia.

References

Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J R QuesadaJ U Gutterman
Feb 1, 1994·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T Vial, J Descotes
May 1, 1995·American Journal of Hematology·J H Lipton, M Minden
Jun 1, 1994·American Journal of Hematology·M HarveyB M Hall
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J V TorregrosaM J Martinez de Osaba
Jul 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K HondaH Nihei
Jun 10, 1998·Annals of Internal Medicine·C L BennettD Green
Apr 29, 1998·Kidney International·P WarwickerJ A Goodship
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I OhsawaY Yamaguchi
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C BadidM Laville
Aug 23, 2002·The New England Journal of Medicine·Joel L Moake
Dec 14, 2004·Journal of the American Society of Nephrology : JASN·Marie-Agnès Dragon-DureyVéronique Frémeaux-Bacchi

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Citations

Jul 20, 2011·Indian Journal of Nephrology·G Li CavoliU Rotolo
Feb 9, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Gwenalyn Garcia, Jean Paul Atallah
May 17, 2017·CEN Case Reports·Haruomi NishioMotoko Yanagita

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