Thrombotic Risks in Red Blood Cell Transfusions

Seminars in Thrombosis and Hemostasis
Timur Dubovoy, Milo Engoren

Abstract

Red blood cells play a key role in normal hemostasis and thrombosis. Their ability to affect coagulation is multifactorial and depends on their mechanical properties affecting viscosity and blood flow, ability to aggregate and adhere to each other and potentially to vascular endothelium, molecular signaling via microvesicles and surface proteins, including blood group antigens, and participation in nitric oxide metabolism. Transfused red blood cells suffer from a storage lesion that damages the cells leading to changes in shape, function, and intracellular communication. In this article, we review if and how transfused red blood cells may lead to both increased hemorrhage and increased thrombosis.

Citations

Mar 3, 2017·Thrombosis and Haemostasis·Michael J R DesboroughSimon J Stanworth
Nov 29, 2016·Antioxidants & Redox Signaling·Viktoria KuhnMiriam M Cortese-Krott
Jan 31, 2018·Anesthesia and Analgesia·Jennifer T MallekLinda Le-Wendling
Jan 9, 2019·Journal of Thrombosis and Haemostasis : JTH·J W Weisel, R I Litvinov
Apr 1, 2021·Free Radical Biology & Medicine·Ali MahdiJohn Pernow
Apr 20, 2021·Frontiers in Pediatrics·Andrea H Gillespie, Allan Doctor

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