Thrombotic stroke in the anesthetized monkey (Macaca mulatta): characterization by MRI--a pilot study

Cerebrovascular Diseases
Maxime GaubertiCyrille Orset

Abstract

The lack of a relevant stroke model in large nonhuman primates hinders the development of innovative diagnostic/therapeutic approaches concerned with this cerebrovascular disease. Our objective was to develop a novel and clinically relevant model of embolic stroke in the anesthetized monkey that incorporates readily available clinical imaging techniques and that would allow the possibility of drug delivery including strategies of reperfusion. Thrombin was injected into the lumen of the middle cerebral artery (MCA) in 12 anesthetized (sevoflurane) male rhesus macaques (Macaca mulatta). Sequential MRI studies (including angiography, FLAIR, PWI, DWI, and gadolinium-enhanced T1W imaging) were performed in a 3T clinical MRI. Physiological and biochemical parameters were monitored throughout the investigations. Once standardized, the surgical procedure induced transient occlusion of the middle cerebral artery in all operated animals. All animals studied showed spontaneous reperfusion, which occurred some time between 2 h and 7 days post-ictus. Eighty percent of the studied animals showed diffusion/perfusion mismatch. The ischemic lesions at 24 h spared both superficial and profound territories of the MCA. Some animals presented hemor...Continue Reading

References

Mar 1, 1978·Stroke; a Journal of Cerebral Circulation·R B MorawetzR M Crowell
Jun 1, 1988·Stroke; a Journal of Cerebral Circulation·Y XieK A Hossmann
Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·G J Del ZoppoE Battenberg
Jul 1, 1971·Stroke; a Journal of Cerebral Circulation·J D Michenfelder, T M Sundt
Nov 1, 1970·Stroke; a Journal of Cerebral Circulation·R M CrowellA Ommaya
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·J M ZabramskiR Macko
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A R YoungJ C Baron
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z ZhangM Chopp
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·J G FrazeeL T Barcliff
Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·UNKNOWN Stroke Therapy Academic Industry Roundtable (STAIR)
Feb 13, 2001·Journal of Neuroscience Methods·G KitoK Minematsu
Mar 13, 2001·Cerebrovascular Diseases·M Alonso de LeciñanaJ M Roda
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y KugeK Minematsu
Aug 14, 2003·Trends in Pharmacological Sciences·A Richard GreenTim Ashwood
Oct 4, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yasuhisa FuruichiTakehiko Yanagihara
Mar 26, 2005·Stroke; a Journal of Cerebral Circulation·Jan SobeskyWolf-Dieter Heiss
Mar 28, 2006·Journal of Pharmacological Sciences·Teruo SusumuGo Kito
Apr 8, 2006·Stroke; a Journal of Cerebral Circulation·Tomohiro OmuraRichard J Roman
Aug 19, 2007·Stroke; a Journal of Cerebral Circulation·Cyrille OrsetDenis Vivien
Aug 31, 2007·Journal of Neurochemistry·Alan R YoungDenis Vivien
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Thomas FreretOmar Touzani
Dec 23, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·M EbingerS M Davis
Feb 24, 2009·Lancet Neurology·Geoffrey A DonnanStephen M Davis
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marc FisherUNKNOWN STAIR Group
Apr 10, 2009·AJNR. American Journal of Neuroradiology·P G Kranz, J D Eastwood
Jun 9, 2009·Neuroscience Research·Yuki SatoTatsuhiro Hisatsune
Oct 2, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ebeline BihelOmar Touzani
Jun 12, 2010·Thrombosis and Haemostasis·A Phillip Owens, Nigel Mackman
Jun 26, 2010·The Journal of Emergency Medicine·Christopher R CarpenterUNKNOWN Best Evidence in Emergency Medicine Investigator Group
Aug 20, 2010·Neurology·T ChemmanamUNKNOWN EPITHET Investigators
Nov 26, 2010·Stroke; a Journal of Cerebral Circulation·Isaac García-YébenesMaría A Moro

❮ Previous
Next ❯

Citations

Nov 21, 2012·PloS One·Anne DurandNorbert Nighoghossian
Dec 21, 2013·Journal of Thrombosis and Haemostasis : JTH·M GaubertiD Vivien
Feb 22, 2012·Cerebrovascular Diseases·Nikolaus Plesnila
Nov 10, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Di WuXunming Ji
Aug 11, 2019·Annals of Clinical and Translational Neurology·LeeAnn RamsaySerge Timsit
Feb 6, 2018·Experimental and Therapeutic Medicine·Jing ChenBo Xu
Oct 3, 2017·Experimental and Therapeutic Medicine·Lixiao PanKexue Zeng
Jun 6, 2019·Stroke; a Journal of Cerebral Circulation·Sean I. SavitzUNKNOWN STAIR X Consortium
Mar 5, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Di WuXunming Ji
May 20, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Justine DebatisseOmer Faruk Eker
Oct 31, 2020·Cellular and Molecular Neurobiology·Chengli LiuWei Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.