Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Nezam TorokRagheb Assaly

Abstract

Goodpasture's disease is associated with circulating anti-glomerular basement membrane (anti-GBM) antibodies. Thrombotic thrombocytopenic purpura (TTP) is a disease related to platelet clumping and microthrombosis in the circulation. We report an unusual case where both entities coexist in the same patient. The patient was a 43-year-old Caucasian male, with a recent history of inhalational hydrocarbon exposure for ~10 weeks. He initially presented with confusion, persistent fever and acute oliguric renal failure. In addition, he was found to be thrombocytopenic and had concurrent microangiopathic haemolytic anaemia. All presenting signs, symptoms and laboratory findings had a temporal relationship within 3 weeks. In addition, he was also found to have active pulmonary hemorrhage and positive anti-GBM antibody. During his stay, the patient underwent treatment with plasmapheresis, and an open lung biopsy, which confirmed the diagnosis of anti-GBM disease. This case report confirms previously reported findings which were noted in a few sporadic case reports about the possible association between Goodpasture's disease and TTP. In addition, it adds to our current understanding of the pathophysiology of autoimmune diseases in general...Continue Reading

References

Nov 1, 1996·Kidney International·W K Bolton
Sep 13, 2003·Kidney International·Charles D Pusey
Jul 21, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wim TerrynRaymond Vanholder

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Citations

Mar 30, 2012·International Urology and Nephrology·Yao-Ko Wen, Kai-I Wen
Mar 25, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jae Il ShinJi Hong Kim
May 30, 2013·Hematology/oncology Clinics of North America·Han-Mou Tsai
Jan 29, 2013·Seminars in Arthritis and Rheumatism·Uzma A SyedaMarina Magrey

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