Thrombotic thrombocytopenic purpura secondary to Streptococcus.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
M J MorrinM F McMullin

Abstract

We describe a 16 year old female who developed thrombotic thrombocytopenic purpura (TTP) following infection due to Streptococcus. Initially presenting a fever and systemic upset she progressed to develop dialysis dependent acute renal failure, seizures, thrombocytopenia and a haemolytic anaemia--the pentad of features seen in TTP. Prior to the diagnosis she was found to have unexplained and previously undescribed MRI findings of diffuse increased signal intensity in the white matter of the left cerebellar hemisphere posteriorly and also increased signal intensity in the overlying cortex. She was commenced on plasmapheresis, and her anaemia, thrombocytopenia, creatinine and LDH all fully responded. In addition, she had no further seizures following plasmapheresis and has not relapsed to date. We review both the rare association of TTP and streptococcal infection, and the neuroradiological findings described in the literature. This is only the third case report describing TTP following streptococcal infection, and only the second in the era of plasmapheresis.

References

Apr 1, 1995·Italian Journal of Neurological Sciences·L FioraniR D'Alessandro
Dec 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K A Myers, T J Marrie
Aug 23, 2002·The New England Journal of Medicine·Joel L Moake

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Citations

Nov 19, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Young Rae KohHyung Hoi Kim
Dec 22, 2010·American Journal of Clinical Pathology·Yara A ParkMark E Brecher
Feb 18, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria K JonssonAstrid Olsnes Kittang
Jan 28, 2021·BMJ Case Reports·Laura Frances WalshBrian Wispelwey
May 19, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Abhijit S GavaliSandip Bartakke

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Methods Mentioned

BETA
PCR
sedation

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