PMID: 8979308Dec 1, 1996Paper

Thromboxane A2 analogue contracts predominantly the hepatic veins in isolated canine liver

Prostaglandins
H UrayamaS Koyama

Abstract

Thromboxane A2 (TxA2) is a potent vasoconstrictor and has been implicated as a mediator of liver diseases such as ischemic-reperfusion injury. We determined the effects of TxA2 and the well-known hepatic venoconstrictor histamine, on the vascular resistance distribution and liver weight in isolated canine livers perfused with blood via the portal vein. The stable TxA2 (STA2; 20 micrograms, n = 5) and histamine (5 micrograms, n = 6) similarly increased the hepatic total vascular resistance, 2.5- and 2.4-fold, respectively. The increase in the hepatic venous resistance was significantly greater than that of the portal resistance (threefold vs. 1.9-fold for STA2; threefold vs. 1.8-fold for histamine). Predominant hepatic venoconstriction induced by both agents was confirmed in livers perfused in a reverse direction from the hepatic vein to the portal vein, as shown by marked precapillary vasoconstriction. STA2 transiently increased liver weight loss (-3.6 g/100 g liver weight), followed by a gradual weight gain (9.0 g/100 g). Histamine caused a progressive weight gain (9.1 g/100 g). In conclusion, similar to histamine, TxA2 constricts predominantly the hepatic vein in isolated canine livers.

References

Jan 1, 1978·Annual Review of Biochemistry·B SamuelssonC Malmsten
Jul 15, 1992·The Biochemical Journal·N KawadaK Decker
May 1, 1992·Journal of Applied Physiology·J W BarnardA E Taylor
Aug 1, 1989·Pediatric Research·S J SoiferM A Heymann
Feb 1, 1989·Journal of Applied Physiology·K YoshimuraL J Rubin
Sep 15, 1988·The New England Journal of Medicine·J A OatesL J Roberts
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S IshiguroT Kitao
Feb 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M ShimadaK Sugimachi

❮ Previous
Next ❯

Citations

Jun 9, 2005·The Journal of Surgical Research·Yukihiro YokoyamaIrshad H Chaudry
Apr 29, 2005·The Japanese Journal of Physiology·Toshishige ShibamotoYasutaka Kurata
Feb 14, 2004·Acta Physiologica Scandinavica·T ShibamotoT Ogura
Feb 7, 2007·Acta Physiologica·N KarasawaH Tsuchida
May 29, 2004·Prostaglandins & Other Lipid Mediators·Zonghai RuanKeishi Kubo
Dec 31, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H G WangS Koyama
Jul 19, 2006·Prostaglandins & Other Lipid Mediators·Sen CuiYasutaka Kurata
Jan 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hongzhi XuJian X Zhang
Jun 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Toshishige ShibamotoYasutaka Kurata
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukihiro YokoyamaJian X Zhang
Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yukihiro YokoyamaIrshad H Chaudry
Oct 4, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zonghai RuanMatomo Nishio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Toshishige ShibamotoYasutaka Kurata
Prostaglandins, Leukotrienes, and Essential Fatty Acids
H G WangS Koyama
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
K KimuraT Sugano
© 2022 Meta ULC. All rights reserved