PMID: 9182072Jan 1, 1997Paper

Thromboxane A2 and related prostaglandins in airways

Fundamental & Clinical Pharmacology
P Devillier, G Bessard

Abstract

Asthma is now thought to be a chronic inflammatory disease of the airways. The roles of prostanoids, thromboxane A2 (TXA2) and the prostaglandins (PGs) in the pathogenesis and pathophysiology of asthma have fostered a wealth of studies but remain controversial. TXA2 and the bronchoconstrictor PGs, PGD2 and PGF2 alpha, are generated in greater amounts in asthmatic than in normal subjects. TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway microvascular leakage. It may participate in the thickening and the remodeling of the airway wall which may contribute to the airway hyperresponsiveness, a typical feature of asthma. Strategies for inhibition of TXA2 effects include antagonism of the TXA2 receptor (TP receptor) and inhibition of the thromboxane synthase. TP receptor antagonists could block the effects of all the bronchoconstrictor prostanoids because TXA2 as well as the bronchoconstrictor PGs act through activation of lung TP receptor. The recent development of specific and potent TP receptor antagonists and inhibitors of thromboxane synthase has provided tools to assess the role of TXA2 and broncho-constrictor PGs in the pathophysiology of asthma.

References

Nov 29, 1978·Biochemical and Biophysical Research Communications·N K HopkinsR R Gorman
Jul 1, 1978·Pharmacological Research Communications·S BiancoP L Kamburoff
Sep 1, 1977·Prostaglandins·J SvenssenM Hamberg
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
May 1, 1975·Clinical Science and Molecular Medicine·A P SmithL S Dunlop
Oct 1, 1992·The Journal of Allergy and Clinical Immunology·U R JuergensB L Zuraw
Jun 1, 1992·Journal of Applied Physiology·J LötvallK F Chung
Jan 10, 1993·The New England Journal of Medicine·E R McFadden, I A Gilbert
Dec 15, 1992·European Journal of Pharmacology·P NormanP J Gardiner
Jun 1, 1992·The Journal of Allergy and Clinical Immunology·H MagnussenA R Baunack
Jun 1, 1992·The American Review of Respiratory Disease·G L JonesP M O'Byrne
Sep 1, 1991·Medicinal Research Reviews·S E Hall
Nov 1, 1991·British Journal of Pharmacology·M G McKenniffP J Gardiner
Jan 1, 1991·The American Review of Respiratory Disease·I K TaylorR W Fuller
Jun 1, 1991·The American Review of Respiratory Disease·K TokuyamaK F Chung
Jan 1, 1990·Drugs·R Williams, C S Lieber
Aug 1, 1990·Archives of Biochemistry and Biophysics·R NüsingV Ullrich
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·C RobinsonS T Holgate
Jun 1, 1987·Journal of Applied Physiology·D C UnderwoodP J Kadowitz
Sep 1, 1989·Journal of Cardiovascular Pharmacology·E A Stein, G J Trachte
Apr 1, 1989·Journal of Applied Physiology·R C BeasleyS T Holgate

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Citations

Aug 19, 2003·European Journal of Pharmacology·Valérie CapraG Enrico Rovati
Oct 29, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SaffakR M Nüsing
Apr 16, 1999·British Journal of Pharmacology·H D HeldS Uhlig
Oct 21, 2003·DNA and Cell Biology·Masahiro Yaekashiwa, Lee-Ho Wang
Nov 15, 2005·Journal of Endourology·Murali K AnkemStephen Y Nakada
May 1, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Styliani GoulopoulouR Clinton Webb
Dec 3, 1998·The Journal of Clinical Investigation·D W ThomasT M Coffman
Mar 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ryan J Van Lieshout, Glenda Macqueen
Aug 8, 2008·Inhalation Toxicology·Shailaja G Mahajan, Anita A Mehta
Feb 7, 2002·Expert Opinion on Investigational Drugs·Jean-Michel DognéBernard Masereel
Sep 15, 1998·Kidney International. Supplement·D W Thomas, T M Coffman
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S-H KimH-D Shin
Jan 13, 2015·Canadian Journal of Physiology and Pharmacology·Jeremy Mark Hernandez, Luke Jeffrey Janssen
Apr 9, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yilin PanManxiang Li
Aug 2, 2005·Immunology and Allergy Clinics of North America·P van CauwenbergeC Bachert
Dec 31, 2008·Pulmonary Pharmacology & Therapeutics·Deborah L ClarkeAkira Yamasaki
Jul 22, 2014·Pediatric Pulmonology·J VeskitkulP Vichyanond
Jan 22, 2002·Pediatric Pulmonology·Amir M KhanGiuseppe N Colasurdo
Dec 17, 2008·Psychosomatic Medicine·Ryan J Van LieshoutGlenda M MacQueen
Sep 7, 2006·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Esin F ErkinAyşin Sakar
May 15, 2007·Pharmacogenetics and Genomics·Sang-Heon KimKyung-Up Min
Mar 11, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lu WangPasquale Chitano
Jul 20, 2011·The Journal of Pharmacology and Experimental Therapeutics·Jeremy Mark Hernandez, Luke Jeffrey Janssen
Apr 19, 2003·Acta Oto-laryngologica·Yoshitaka TakiguchiKen Kitamura
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Jean-Michel DognéBernard Masereel
Nov 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N S PalikheH-S Park
Jun 17, 2003·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Toshihiko FukuokaYasuyuki Yoshizawa
Dec 13, 2006·Molecular Diagnosis & Therapy·Miles D ThompsonDavid E C Cole
Sep 17, 2004·Pharmacology & Therapeutics·Aaron N Hata, Richard M Breyer
Feb 7, 2006·European Journal of Pharmacology·Stéphanie RolinJean-Michel Dogné
Apr 1, 2008·Pharmacology & Therapeutics·Norimichi Nakahata

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