Thromboxane A2 generation by the larval cestode, Taenia taeniaeformis

Clinical Immunology and Immunopathology
R W Leid, L A McConnell

Abstract

The larval stage of the tapeworm, Taenia taeniaeformis, was incubated in different concentrations of arachidonic acid. At various times after incubation, aliquots were removed for bioassay on either 38 microM aspirin or non-aspirin-treated equine platelets and by radioimmunoassay for the thromboxane A2 breakdown product, thromboxane B2 (TXB2). Platelet agonist activity was detected as early as 30 sec after addition of the arachidonic acid. In aspirin-treated platelets, this agonist activity peaked at 1 to 4 min and thereafter decayed rapidly with a time course that was both worm and arachidonic acid dependent. When assayed on non-aspirin-treated platelets the agonist activity was again detectable as early as 30 sec after addition of arachidonic acid, peaked at 1 to 3 min and then decayed very slowly over a 30-min period of incubation. It was found that levels of TXB2 were detected which increased over time concomitant with the decay of the platelet agonist activity. The most consistent detection of TXB2 generation was at 30 min with a mean of 49.6 pg and a range of 22.1 to 84.8 pg for four experiments. This report presents the first evidence for arachidonic acid utilization by a cestode or trematode and could in part provide an...Continue Reading

References

Jan 1, 1969·Lipids·T M SmithH B White
Mar 1, 1981·Prostaglandins·E GulbisE Schell-Frederick

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Citations

Aug 1, 1989·Experimental Parasitology·L X Liu, P F Weller
Jan 1, 1989·Parasitology Research·A DaugschiesH O Hoppen
Jun 1, 1983·Inflammation·C M Suquet, R W Leid
Dec 4, 2001·Biochimica Et Biophysica Acta·G AlviteA Esteves
Aug 1, 1984·Veterinary Immunology and Immunopathology·H D LiggittL Huston
Apr 1, 1987·Molecular and Biochemical Parasitology·D L LongworthP F Weller
Jul 1, 1987·Veterinary Parasitology·R W LeidL Tanigoshi
Nov 1, 1990·Experimental Parasitology·L X Liu, P F Weller

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