PMID: 9192091Jun 1, 1997Paper

Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cells

Biochemistry and Molecular Biology International
S JariyawatH Endou

Abstract

The purpose of this study was to elucidate the role of thromboxane A2 (TXA2) in cisplatin-induced apoptosis of mouse renal cells derived from the terminal proximal tubule (S3). RT-PCR analysis revealed that S3 cells express TXA2 receptor mRNA. A TXA2 receptor antagonist, KW-3635, dose-dependently inhibited cisplatin-induced apoptosis of S3 cells. Treatment of S3 cells with a TXA2 agonist, STA2, induced a significant decrease in their viability and resulted in the characteristic ladder pattern resulting from intranucleosomal DNA cleavage. Treatment with KW-3635 resulted in attenuation of the increase in c-fos mRNA expression level in cisplatin-treated S3 cells. In conclusion, TXA2 appears to mediate cisplatin-induced apoptosis of S3 cells by inducing an increase in the level of c-fos mRNA expression.

Citations

Aug 8, 2008·American Journal of Physiology. Renal Physiology·Helene FrancoisThomas M Coffman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.