Thromboxane biosynthesis in allergen-induced bronchospasm. Evidence for platelet activation

The American Review of Respiratory Disease
M D LupinettiG A FitzGerald

Abstract

To determine if platelet activation occurs after allergen inhalation in atopic asthmatics, we measured two urinary metabolites of the principal cyclooxygenase product of platelets, thromboxane A2 (TxA2), using the sensitive and specific technique of gas chromatography-negative ion, chemical ionization-mass spectrometry. Seven atopic asthmatics underwent allergen challenge after low dose aspirin to suppress platelet thromboxane generation and on placebo days. On placebo days, the urinary levels of 2,3-dinor-TxB2 increased from 76 +/- 22 pg/mg creatinine to 216 +/- 95 after allergen, and 11-dehydro-TxB2 from 396 +/- 98 to 627 +/- 137 (p less than 0.05). Low dose aspirin suppressed excretion of urinary thromboxane metabolites and prevented the rise after allergen inhalation without altering the bronchoconstriction. Excretion of 2,3-dinor-6-keto-PGF1 alpha, a metabolite of prostacyclin, was unaltered by this aspirin regimen. We conclude that platelets are activated after allergen challenge, but that platelet-derived TxA2 is not important in the early bronchoconstrictor response.

References

Sep 1, 1977·Analytical Biochemistry·F A FitzpatrickF F Sun
Nov 21, 1991·The New England Journal of Medicine·M A ShumanK J Hittelman
Feb 1, 1988·The American Journal of Physiology·K Sato, F Sato
Aug 1, 1987·American Journal of Obstetrics and Gynecology·D J FitzgeraldG A FitzGerald
Sep 15, 1987·Thrombosis Research·F Catella, G A FitzGerald
Mar 4, 1982·The New England Journal of Medicine·S Butman
Jun 4, 1981·The New England Journal of Medicine·K A KnauerJ E Fish

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Citations

Dec 22, 2011·Clinical Reviews in Allergy & Immunology·Christopher Chang
Apr 9, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C FukushimaS Asai
Dec 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C FukushimaK Hara
Sep 19, 2002·American Journal of Therapeutics·Amir Pelleg, Edward S Schulman
Jun 15, 2010·Clinical Lipidology·Emer M Smyth
Jan 28, 2014·The Journal of Allergy and Clinical Immunology·Kameran DahamBarbro Dahlén
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TornhamreJ A Lindgren
Dec 30, 2014·Expert Review of Respiratory Medicine·Dru ClaarRay Stokes Peebles
Aug 31, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Laura B Fanning, Joshua A Boyce
May 26, 2007·The American Journal of Pathology·Risa Tamagawa-MineokaSaburo Kishimoto
Feb 17, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Risa Tamagawa-MineokaSaburo Kishimoto
May 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F C Thien, E H Walters
Jan 28, 2014·Annals of Medicine·Vincent Yi-Fong SuChia-Jen Liu
Sep 18, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Risa Tamagawa-MineokaSaburo Kishimoto
Apr 9, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yilin PanManxiang Li
Nov 8, 2016·Expert Review of Respiratory Medicine·Kevin A Cook, Donald D Stevenson
Jul 11, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SzczeklikC Virchow
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W Ind
Oct 13, 2006·Clinical and Experimental Immunology·N KatohS Kishimoto
Nov 23, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-H KimS-J Hong
Jan 1, 1993·Platelets·C M Herd, C P Page
Mar 8, 2019·Journal of Lipid Research·Cristina GómezCraig E Wheelock
Jul 16, 2020·American Journal of Respiratory and Critical Care Medicine·Johan KolmertUNKNOWN U-BIOPRED Study Group, on behalf of the U-BIOPRED Study Group

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