PMID: 3772299Nov 1, 1986Paper

Thromboxane generation by human monocytes enhances platelet function

The Journal of Experimental Medicine
D C Altieri, P M Mannucci

Abstract

Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. The enhancement of platelet function is rapid, relatively transient and is due to thromboxane (Tx) synthesized by monocytes under these conditions. Tx generation by monocytes is triggered by the interaction between fibrinogen and the specific monocyte membrane receptor. These data suggest that the monocyte enhancement of platelet function combined with the clot-promoting activity of these cells might unbalance normal hemostasis.

References

Oct 1, 1986·The Journal of Clinical Investigation·D C AltieriA M Capitanio
Jan 1, 1981·The Journal of Experimental Medicine·M P BevilacquaC Bianco
Oct 1, 1981·The Journal of Clinical Investigation·J S BennettJ W Burch
Aug 1, 1983·The Journal of Experimental Medicine·N A PawlowskiW A Scott
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C A RouzerZ A Cohn
May 1, 1981·The Journal of Clinical Investigation·C Ingerman-WojenskiE Macarak

❮ Previous
Next ❯

Citations

Aug 1, 1989·The Journal of Clinical Investigation·R L SilversteinR L Nachman
Apr 4, 2021·Journal of Fungi·Susana Ruiz MendozaAllan J Guimarães

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.