PMID: 702055Sep 1, 1978Paper

Thromboxane generation by human peripheral blood polymorphonuclear leukocytes

The Journal of Experimental Medicine
I M GoldsteinG Weissmann

Abstract

Human peripheral blood polymorphonuclear leukocytes were stimulated to generate thromboxane B2 in a time- and concentration-dependent fashion upon exposure to serum-treated zymosan particles. Conversion by stimulated PMN of [14C] arachidonic acid to [14C]thromboxane B2 was confirmed by thin-layer radiochromatography, radio-gas chromatography, and mass spectrometry. Generation of thromboxane B2 was independent of platelet contamination and could be inhibited by the cyclooxygenase inhibitor, indomethacin. Cells rendered incapable of ingesting particles by treatment with cytochalasin B generated comparable amounts of thromboxane B2. These results suggest that human peripheral blood polymorphonuclear leukocytes synthesize thromboxanes in response to surface stimulation independently of phagocytosis.

References

Nov 1, 1975·The Journal of Clinical Investigation·I M GoldsteinG Weissmann
Jan 13, 1977·Nature·F A KuehlC G Van Arman
Nov 1, 1976·Acta Physiologica Scandinavica·J SvenssonB Samuelsson
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·R B ZurierG Weissmann
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Mar 1, 1974·The Journal of Clinical Investigation·J E Smolen, S B Shohet

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Citations

Sep 1, 1995·Journal of Biomedical Materials Research·E SolheimE Sudmann
Feb 1, 1991·Journal of Cellular Physiology·H ZhengT A Raffin
Sep 1, 1979·Inflammation·J T O'FlahertyP A Ward
Jun 1, 1982·Inflammation·G EggerD Gollmann
Sep 15, 1984·Experientia·M Baggiolini
Aug 1, 1983·Agents and Actions·H Bult, A G Herman
Dec 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·C LechiA Lechi
Jul 11, 1994·European Journal of Pharmacology·T NagaoY Suzuki
Feb 1, 1993·The International Journal of Biochemistry·T Siminiak, T Ozawa
Jun 1, 1979·Prostaglandins·J T O'FlahertyP A Ward
Jan 1, 1981·Progress in Lipid Research·J W SchmelingP W Ramwell
Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H TakayamaH Uchino
Aug 1, 1984·Prostaglandins, Leukotrienes, and Medicine·K Punnonen, P Uotila
Jun 1, 1985·Prostaglandins, Leukotrienes, and Medicine·P MadernaE Tremoli
Nov 28, 1996·European Journal of Pharmacology·T NagaoY Suzuki
Jul 3, 1980·The New England Journal of Medicine·G WeissmannH M Korchak
Apr 23, 1981·The New England Journal of Medicine·R M RobertsonJ A Oates
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D A BassC E McCall
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S AbramsonG Weissmann
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M ChignardJ B Smith
Aug 1, 1983·The Journal of Experimental Medicine·N A PawlowskiW A Scott
Apr 2, 1984·European Journal of Biochemistry·M BirmelinK Decker

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