PMID: 1749204Sep 16, 1991Paper

Thromboxane production and platelet aggregation in type 2 diabetes mellitus without vascular complications

Klinische Wochenschrift
K P RatzmannC Taube

Abstract

Diabetic individuals frequently have platelet hyperaggregability and increased thromboxane (TXB2) production. To evaluate whether improvement of metabolic control or changes in fatty acid composition of serum lipids might alter thromboxane (TXB2) formation and platelet function, we followed up 25 newly diagnosed type 2 diabetics without angiopathy for about 6 months. Improvement of metabolic control (HbA1, fell from 12.0 +/- 0.3 to 9.0 +/- 0.3%; p less than 0.01) was associated with significant decrease in total cholesterol, triglycerides, and ratios of total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol. Palmitic acid of phospholipids decreased significantly, whereas eicosapentaenoic acid increased. Regardless of this, the ADP-induced platelet aggregability and sensitivity were not altered. There was no effect whatever on the TXB2 synthesis capacity of clotting whole blood (204.9 +/- 25.0 vs 222.8 +/- 32.0 ng/ml) over 6 months of treatment. Platelet aggregability and TXB2 formation were not correlated to the degree of metabolic control, nor were there any correlations to serum lipids and their fatty acid composition. Thus, we are tempted to speculate that glucose metabolism in diabetes itself does not affect ...Continue Reading

References

Mar 1, 1978·Diabetes·M M Bern
Aug 1, 1977·Clinical Endocrinology·R A MooreJ I Mann
Mar 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T Hendra, D J Betteridge
Oct 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R S Tilvis, T A Miettinen
Oct 1, 1982·Prostaglandins, Leukotrienes, and Medicine·C TaubeW Förster
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS

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Citations

Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y RodríguezA B Christophe

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