Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease

Hypertension
Cheng WangDan Wang

Abstract

Cardiovascular disease is frequent in chronic kidney disease and has been related to angiotensin II, endothelin-1 (ET-1), thromboxane A2, and reactive oxygen species (ROS). Because activation of thromboxane prostanoid receptors (TP-Rs) can generate ROS, which can generate ET-1, we tested the hypothesis that chronic kidney disease induces cyclooxygenase-2 whose products activate TP-Rs to enhance ET-1 and ROS generation and contractions. Mesenteric resistance arterioles were isolated from C57/BL6 or TP-R+/+ and TP-R-/- mice 3 months after SHAM-operation (SHAM) or surgical reduced renal mass (RRM, n=6/group). Microvascular contractions were studied on a wire myograph. Cellular (ethidium: dihydroethidium) and mitochondrial (mitoSOX) ROS were measured by fluorescence microscopy. Mice with RRM had increased excretion of markers of oxidative stress, thromboxane, and microalbumin; increased plasma ET-1; and increased microvascular expression of p22(phox), cyclooxygenase-2, TP-Rs, preproendothelin and endothelin-A receptors, and increased arteriolar remodeling. They had increased contractions to U-46,619 (118 ± 3 versus 87 ± 6, P<0.05) and ET-1 (108 ± 5 versus 89 ± 4, P<0.05), which were dependent on cellular and mitochondrial ROS, cycl...Continue Reading

References

Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M L PurkersonS Klahr
Apr 25, 2000·The Journal of Laboratory and Clinical Medicine·H C ChenY H Lai
Oct 15, 2003·Circulation·Damiano RizzoniEnrico Agabiti-Rosei
Oct 30, 2003·The Journal of Biological Chemistry·François ValentinJohn R Tippins
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Rhian M TouyzErnesto L Schiffrin
Jun 24, 2004·American Journal of Physiology. Renal Physiology·Noritaka KawadaChristopher S Wilcox
Jul 15, 2004·Seminars in Nephrology·Paul S ModlingerShakil Aslam
Jan 5, 2006·Hypertension·Paul ModlingerChristopher S Wilcox
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dan WangChristopher S Wilcox
May 20, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Emilie C VielErnesto L Schiffrin
Nov 6, 2008·Archives of Biochemistry and Biophysics·Stefan Schildknecht, Volker Ullrich
May 27, 2009·British Journal of Pharmacology·Z LuoC S Wilcox
Feb 16, 2010·Pharmacology & Therapeutics·Christopher S Wilcox
Jun 3, 2010·Hypertension·Yaz Y KisanukiMasashi Yanagisawa
Aug 11, 2010·Hypertension·Zaiming LuoChristopher S Wilcox
Nov 3, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin J LandrayDavid C Wheeler
Feb 22, 2011·Analytical and Bioanalytical Chemistry·Andrey V KuznetsovJakob Troppmair
Dec 14, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuh Fen PungWilliam M Chilian
Dec 29, 2011·Hypertension·Ernesto L Schiffrin
Apr 12, 2012·American Journal of Physiology. Renal Physiology·En Yin LaiChristopher S Wilcox
Jul 21, 2012·Current Hypertension Reports·Debbie L Cohen, Raymond R Townsend
Mar 12, 2013·Antioxidants & Redox Signaling·Magali Araujo, Christopher S Wilcox
Jan 21, 2014·Progress in Cardiovascular Diseases·Jongha ParkKamyar Kalantar-Zadeh
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Dick de ZeeuwHans-Henrik Parving
May 9, 2014·Kidney International·Donald E Kohan, Matthias Barton
Jul 6, 2014·American Journal of Respiratory Cell and Molecular Biology·Omar A JafferMark E Anderson
Aug 15, 2014·Kidney & Blood Pressure Research·Antonio Santoro, Marcora Mandreoli

❮ Previous
Next ❯

Citations

Mar 17, 2017·Antioxidants & Redox Signaling·Xuehong LiuNabil J Alkayed
Dec 3, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ammar Al-MashhadiMattias Carlstrom
Nov 24, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cheng WangDan Wang
Jun 15, 2018·Oncotarget·Yuanyuan LiYue Zhang
Dec 14, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yukihito NakanoShuji Arima
Oct 24, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·L LiC S Wilcox
Jul 13, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hicham Labazi, Aaron J Trask

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.