Thrombus Aspiration in Patients With ST-Segment Elevation Myocardial Infarction Presenting Late After Symptom Onset

JACC. Cardiovascular Interventions
Steffen DeschHolger Thiele

Abstract

The aim of this study was to examine whether manual thrombus aspiration reduces microvascular obstruction assessed by cardiac magnetic resonance imaging in patients with ST-segment elevation myocardial infarction (STEMI) presenting late after symptom onset. Thrombus aspiration is an established treatment option in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). However, there are only limited data on the efficacy of thrombus aspiration in patients with STEMI presenting ≥12 h after symptom onset. Patients with subacute STEMI presenting ≥12 and ≤48 h after symptom onset were randomized to primary PCI with or without manual thrombus aspiration in a 1:1 ratio. Patients underwent cardiac magnetic resonance imaging 1 to 4 days after randomization. The primary endpoint was the extent of microvascular obstruction. A total of 152 patients underwent randomization. The mean time between symptom onset and PCI was 28 ± 12 h. Baseline characteristics were comparable between groups. The majority of patients (60%) showed at least a moderate amount of viable myocardium in the affected region. Extent of microvascular obstruction was not significantly different between patients assigned to thrombus aspiration and ...Continue Reading

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Citations

Jan 23, 2016·JACC. Cardiovascular Interventions·James C Blankenship
Mar 21, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·James C Blankenship
Oct 4, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Eddie D Brown, James C Blankenship
Feb 14, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·André LuzHenrique Carvalho
Nov 20, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·James C Blankenship
Mar 13, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Anne FreundSteffen Desch
Feb 9, 2017·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Peter Nørkjær LaursenJ Lønborg
Mar 15, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Anne FreundSteffen Desch
Oct 17, 2019·Basic Research in Cardiology·Gerd Heusch
Feb 8, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Hans-Josef FeistritzerHolger Thiele

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