Thrombus Formation After Left Atrial Appendage Occlusion With the Amplatzer Amulet Device

JACC. Clinical Electrophysiology
Alexander SedaghatChristoph Hammerstingl

Abstract

This study sought to define the ideal post-procedural anticoagulant regime and to systematically study the incidence of device-related thrombus. Left atrial appendage occlusion (LAAo) is an alternative to life-long oral anticoagulation in selected patients with atrial fibrillation. This study included 24 atrial fibrillation patients (ages 79 ± 8 years; 75% male, CHA2DS2VASc [Congestive Heart Failure, Hypertension, Age ≥75 Years, Diabetes Mellitus, Previous Stroke or Transient Ischemic Attack or Thromboembolism, Vascular Disease, Age 65 to 74 Years. Sex] score: 4.3 ± 1.5, HAS-BLED [Hypertension, Abnormal Renal and Liver Function, Stroke, Bleeding, Labile International Normalized Ratio, Elderly, Drugs or Alcohol] score: 3.6 ± 0.8) after LAAo with the use of the Amplatzer Amulet system. Dual antiplatelet therapy for 3 months was prescribed in 95.6% of the cases. Transesophageal echocardiography identified a high rate of device adherent thrombi (16.7%, n = 4 of 23) after a mean of 11.0 ± 8.2 weeks. Thrombus formation occurred under dual antiplatelet therapy (3 of 4) or clopidogrel monotherapy (1 of 4). When compared with patients without thrombi, echocardiography showed higher degrees of spontaneous echo contrast grades within the ...Continue Reading

References

Aug 21, 2010·JACC. Cardiovascular Interventions·Robert S SchwartzRenu Virmani
Jan 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Xavier FreixaRéda Ibrahim
Jan 26, 2013·Thrombosis and Haemostasis·Christoph HammerstinglGeorg Nickenig
Jun 22, 2013·JACC. Cardiovascular Interventions·Bjoern PlichtRaimund Erbel
Sep 30, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Boris S LoweAllan L Klein
Oct 22, 2014·Circulation·Michael D Ezekowitz, Anthony P Kent
Jan 22, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Apostolos TzikasJai-Wun Park
Dec 17, 2015·International Journal of Cardiology·Ulrike KettererStephan Kische

❮ Previous
Next ❯

Citations

Nov 29, 2017·Herzschrittmachertherapie & Elektrophysiologie·Martin W Bergmann, Carsten W Israel
Nov 18, 2017·Circulation. Cardiovascular Interventions·Lluis Asmarats, Josep Rodés-Cabau
Feb 8, 2018·European Heart Journal Cardiovascular Imaging·Hubert CochetJean-Benoît Thambo
Aug 11, 2020·Circulation. Cardiovascular Interventions·Lluis AsmaratsJosep Rodés-Cabau
Jun 25, 2019·Frontiers in Cardiovascular Medicine·Anna Olasinska-Wisniewska, Marek Grygier
Apr 21, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dominik NellesAlexander Sedaghat
Jan 9, 2021·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexander SedaghatUNKNOWN EWOLUTION study group
Mar 7, 2021·Journal of Clinical Medicine·Krzysztof KaczmarekMarek Grygier
Oct 12, 2018·Heart, Lung & Circulation·Michaël PeyrolLaurent Bonello
May 19, 2021·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Mohamad Jihad MansourJacques Mansourati

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.