Thrombus formation and microaggregate removal during extracorporeal membrane oxygenation

Journal of Biomedical Materials Research
R G GuidoinP Blais

Abstract

Contemporary microporous membrane oxygenators have adequate gas transfer capacity and even prolonged oxygenation is relatively atraumatic to the blood elements. However, even with adequate heparinization, thrombus formation still takes place, albeit to a lesser degree than in direct blood-gas contact devices. In this work, scanning electron microscopy of the dissected devices in the extracorporeal circuit was performed on devices used during four aorto-coronary bypasses and two cardiac valve replacements. Membrane surfaces remained free of major deposits although thrombotic material could still be observed in parts of the oxygenators and the filters. Blood filtration from the cardiotomy reservoir may be more critical as it removes surgical debris and cells injured by suction which appear to enhance thrombus formation within the oxygenator. The return line arterial filter appears more useful as a bubble remover; its value appears much diminished as microemboli do not leave the device in large quantities.

References

Feb 1, 1976·The Annals of Thoracic Surgery·A C BeallM E DeBakey
May 11, 1975·Annals of Surgery·J E LiddicoatM E DeBakey
Jan 1, 1976·International Anesthesiology Clinics·W M ZapolM Rie
Jan 1, 1974·Scandinavian Journal of Haematology·M D Schneider
Jan 1, 1973·Biomaterials, Medical Devices, and Artificial Organs·A RembaumC L Hu
Jun 1, 1970·Journal of Biomedical Materials Research·A LautierA Sausse

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Citations

Aug 25, 1976·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R G GuidoinD Domurado
Jun 12, 1978·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R GuidoinJ P Gille
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J RoyJ Awad
Feb 1, 1985·Artificial Organs·P M Knight, D J Lyman

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