Abstract
Recent studies suggest that conservative management with antithrombotic therapy without stenting may be an option in selected patients with acute coronary syndrome (ACS). We evaluated whether a glycoprotein IIb/IIIa inhibitor, tirofiban, would offer additional benefit in patients with plaque erosion presenting with ACS who were treated with antiplatelet therapy without stenting. Forty-nine patients who completed 1-year follow-up optical coherence tomography imaging in the EROSION study were divided into two groups: tirofiban (n=32) versus no tirofiban (n=17). Thrombus volume, thrombus burden, and the incidence of major adverse cardiovascular events were evaluated. At baseline, the tirofiban group had similar thrombus volume [3.73 (1.27-12.49) vs. 3.51 (1.70-8.65) mm, P=0.983] and marginally greater thrombus burden [17.9 (10.1-26.1) vs. 10.6 (6.8-19.0)%, P=0.097]. At 1 month, the tirofiban group had smaller residual thrombus volume [0.00 (0.00-1.78) vs. 0.94 (0.07-4.20) mm, P=0.054], thrombus burden [0.0 (0.0-6.4) vs. 7.0 (1.8-14.8)%, P=0.024], and greater reduction of thrombus volume (85.4±24.6 vs. 67.1±27.1%, P=0.021). These differences were maintained up to 1 year. Complete resolution of thrombus at 1 month was more frequent ...Continue Reading
References
Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Apr 1, 1996·Circulation·A FarbR Virmani
Aug 24, 1999·Heart·E ArbustiniR Virmani
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Mar 18, 2005·Heart·Y SatoY Asada
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
Jun 13, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Apr 1, 2008·JAMA : the Journal of the American Medical Association·Marco ValgimigliUNKNOWN Multicentre Evaluation of Single High-Dose Bolus Tirofiban vs Abciximab With Sirolimus-Eluting Stent or Bare Metal Stent in
Nov 7, 2009·European Heart Journal·Francesco PratiUNKNOWN Expert's OCT Review Document
Nov 28, 2009·Journal of the American College of Cardiology·Robert S SchwartzRenu Virmani
Jun 1, 2010·Journal of the American College of Cardiology·Jurriën M ten BergUNKNOWN On-TIME 2 Study Group
Jun 2, 2012·European Heart Journal·Francesco PratiUNKNOWN Expert's OCT Review Document
Dec 22, 2012·Journal of the American College of Cardiology·Patrick T O'GaraDavid X Zhao
Mar 12, 2013·JACC. Cardiovascular Imaging·Francesco PratiJagat Narula
Jul 3, 2013·Journal of the American College of Cardiology·Haibo JiaIk-Kyung Jang
Dec 24, 2013·Journal of the American College of Cardiology·Sining HuIk-Kyung Jang
Apr 30, 2014·Nature Reviews. Cardiology·Fumiyuki OtsukaJagat Narula
Jun 7, 2014·Circulation Research·Deepak L BhattRobert A Harrington
Sep 25, 2014·Circulation·Ezra A AmsterdamSusan J Zieman
Nov 28, 2014·European Heart Journal Cardiovascular Imaging·N AmabileC Caussin
Jan 17, 2015·Investigative Ophthalmology & Visual Science·Michaël J A GirardNicholas G Strouthidis
Jan 31, 2015·Atherosclerosis·Kazuyuki YahagiRenu Virmani
Jun 29, 2015·JACC. Cardiovascular Interventions·Takumi HigumaIk-Kyung Jang
Jul 19, 2015·Vascular Pharmacology·Shawn KingCassidy Harmon
Nov 23, 2015·International Journal of Cardiology·Taishi YonetsuTsunekazu Kakuta
Jan 6, 2017·European Heart Journal·Peter Libby
Jul 1, 2015·Interventional Cardiology Clinics·Daniel S Ong, Ik-Kyung Jang
Dec 17, 2017·Circulation. Cardiovascular Interventions·Lei XingIk-Kyung Jang
Citations
Sep 22, 2020·Journal of Thrombosis and Thrombolysis·Osamu KuriharaIk -Kyung Jang
Oct 24, 2019·Journal of the American Heart Association·Erika YamamotoIk-Kyung Jang
Nov 10, 2020·Journal of Medical Case Reports·Keisuke ShojiSatoaki Matoba
Jul 6, 2021·European Heart Journal. Case Reports·Isabel Muñoz PousaVictor A Jiménez Díaz
Jul 19, 2021·Journal of Thrombosis and Thrombolysis·Akihiro NakajimaIk-Kyung Jang