Through-needle all-optical ultrasound imaging in vivo: a preclinical swine study.

Light, Science & Applications
Malcolm C FinlayAdrien E Desjardins

Abstract

High-frequency ultrasound imaging can provide exquisite visualizations of tissue to guide minimally invasive procedures. Here, we demonstrate that an all-optical ultrasound transducer, through which light guided by optical fibers is used to generate and receive ultrasound, is suitable for real-time invasive medical imaging in vivo. Broad-bandwidth ultrasound generation was achieved through the photoacoustic excitation of a multiwalled carbon nanotube-polydimethylsiloxane composite coating on the distal end of a 300-μm multi-mode optical fiber by a pulsed laser. The interrogation of a high-finesse Fabry-Pérot cavity on a single-mode optical fiber by a wavelength-tunable continuous-wave laser was applied for ultrasound reception. This transducer was integrated within a custom inner transseptal needle (diameter 1.08 mm; length 78 cm) that included a metallic septum to acoustically isolate the two optical fibers. The use of this needle within the beating heart of a pig provided unprecedented real-time views (50 Hz scan rate) of cardiac tissue (depth: 2.5 cm; axial resolution: 64 μm) and revealed the critical anatomical structures required to safely perform a transseptal crossing: the right and left atrial walls, the right atrial ap...Continue Reading

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Citations

Nov 15, 2018·Sensors·Pil Gyu SangHyoung Won Baac
Apr 5, 2019·Scientific Reports·Richard J ColchesterAdrien E Desjardins
Oct 17, 2018·Light, Science & Applications·Rehman AnsariPaul C Beard
Mar 7, 2019·Light, Science & Applications·Georg WissmeyerVasilis Ntziachristos
Jul 14, 2018·Optics Letters·Chenfei HuGabriel Popescu
Sep 13, 2019·Optics Express·Salvatore La CaveraMatt Clark
Oct 20, 2018·Biomedical Optics Express·Erwin J AllesAdrien E Desjardins
Jun 2, 2018·Journal of Healthcare Engineering·Tianrui ZhaoWenfeng Xia
Nov 12, 2020·Frontiers in Cardiovascular Medicine·Callum D LittleRoby D Rakhit
Apr 9, 2021·Visual Computing for Industry, Biomedicine and Art·Wu YangWei Song
Apr 29, 2021·Light, Science & Applications·Salvatore La CaveraMatt Clark
Nov 10, 2020·Photoacoustics·Jingcheng Zhou, Jesse V Jokerst
Jul 20, 2021·Ultrasonics·Erwin J AllesAdrien E Desjardins
Nov 5, 2021··Bai-Ou GuanLong Jin
Jul 19, 2019··Adrien E. DesjardinsErwin J. Alles

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Methods Mentioned

BETA
X-ray
ICE

Software Mentioned

LabVIEW
Matlab

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